From the Laboratory to the Clinic: Molecular Treatment of Heart Failure

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dc.authorscopusid57218547849en_US
dc.authorscopusid56078893600en_US
dc.contributor.authorAlagoz, Mehmet
dc.contributor.authorAlpay, Merve
dc.date.accessioned2024-08-23T16:03:49Z
dc.date.available2024-08-23T16:03:49Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCoronary and cardiovascular diseases are the leading cause of death today, with heart failure being among the primary culprits. Heart failure can occur as a result of many diseases, so research in this area is important in terms of clinical outcomes and treatment. Histopathology of heart failure includes cardiac hypertrophy, inflammation, angiogenesis, and apoptosis pathways. The issue of elucidating the pathology of heart failure is still an area of active research. In advanced heart failure, the typical management strategy is medical treatment, mechanical ventricular support devices, and heart transplantation. Heart failure, which occurs with modifiable and non -modifiable risk factors, can be controlled with both nonpharmacological and pharmacological treatment applications. It is especially important to focus on new treatment methods and introduce them to the clinic. Although they are all not yet used in clinics, many studies have yielded promising results with molecular treatment options for heart failure prevention. Studies in animals have shown that heart failure stops proceeding when angiogenesis is induced. Promising results have also been achieved with stem cell therapy, but these may not be implementable for years. It is expected that studies following phases 1 and 2, of the studies which had positive results in the treatment of heart failure, will be conducted and applied in the daily treatment practice.en_US
dc.identifier.doi10.18678/dtfd.1435020
dc.identifier.endpage8en_US
dc.identifier.issn1307-671X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85192464050en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage3en_US
dc.identifier.trdizinid1232342en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1435020
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1232342
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13916
dc.identifier.volume26en_US
dc.identifier.wosWOS:001260510700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeart failureen_US
dc.subjectmolecular treatmenten_US
dc.subjectstem cell therapyen_US
dc.subjectCardiac Myocyte Apoptosisen_US
dc.subjectRisk-Factorsen_US
dc.subjectStem-Cellsen_US
dc.subjectManagementen_US
dc.subjectLifeen_US
dc.subjectTranscriptionen_US
dc.subjectAngiogenesisen_US
dc.subjectHypertrophyen_US
dc.titleFrom the Laboratory to the Clinic: Molecular Treatment of Heart Failureen_US
dc.typeArticleen_US

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