Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia

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dc.contributor.authorBarlas, İbrahim Ömer
dc.contributor.authorSemiz, Ümit
dc.contributor.authorErdal, M.E.
dc.contributor.authorAlgül, Ayhan
dc.contributor.authorAy, Özlem
dc.contributor.authorAteş, M.A.
dc.contributor.authorHerken, Hasan
dc.date.accessioned2020-04-30T22:39:50Z
dc.date.available2020-04-30T22:39:50Z
dc.date.issued2012
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Matematik Bölümüen_US
dc.descriptionErdal, Mehmet Emin/0000-0002-6191-2930; barlas, ibrahim omer/0000-0002-2645-4487; Ankarali, Handan Camdeviren/0000-0002-3613-0523; Algul, Ayhan/0000-0002-6570-7141en_US
dc.descriptionWOS: 000304344800009en_US
dc.descriptionPubMed: 26953012en_US
dc.description.abstractBarlas IO, Semiz U, Erdal ME, Algul A, Ay OI, Ates MA, Camdeviren H, Basoglu C, Herken H. Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia. Objectives: The heterogeneity of schizophrenia mainly results from variations in clinical expressions of the disease, such as age at onset, gender differences in onset of illness, symptoms and response to antipsychotic treatment. Enhanced sensitisation of dopamine pathways in males, having consistently an earlier onset, might be implicated as disease modifiers for schizophrenia in males. Methods: In this study, we performed a case (n = 87)-control (n = 100) association study between the DBH5'-ins/del and DBH-444g/a polymorphisms of the DBH gene and also compared the level of psychotic symptoms between patients with different DBH genotypes/haplotypes with respect to antipsychotic therapeutic response and gender difference. Results: No significant differences between allele and genotype and haplotype frequencies at either groups (p < 0.05). When the age is considered in patient group, a significant difference was observed between patients with ID genotype and with II genotype (p = 0.018). Patients with ID genotype have been diagnosed as schizophrenics in early ages when compared to II genotype carriers. We also found a significant difference between II and ID genotype (p = 0.007) when the gender had taken into account, showing that the ID genotype carriers had an early onset to schizophrenia. Conclusions: This association was more significant in male schizophrenia patients than females. Thus, this finding may constitute a novel biological support for the prior finding that onset of schizophrenia varies with gender. The results also showed that critical genetic vulnerability may be associated with the presence or absence of the ID genotype of DBH5'-ins/del.en_US
dc.identifier.doi10.1111/j.1601-5215.2011.00617.xen_US
dc.identifier.endpage182en_US
dc.identifier.issn1601-5215
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage176en_US
dc.identifier.urihttps://doi.org/10.1111/j.1601-5215.2011.00617.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2840
dc.identifier.volume24en_US
dc.identifier.wosWOS:000304344800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectage at onseten_US
dc.subjectdopamine beta hydroxylaseen_US
dc.subjectmale genderen_US
dc.subjectpolymorphismen_US
dc.subjectschizophreniaen_US
dc.titleAssociation between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophreniaen_US
dc.typeArticleen_US

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