Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge Univ Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Barlas IO, Semiz U, Erdal ME, Algul A, Ay OI, Ates MA, Camdeviren H, Basoglu C, Herken H. Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia. Objectives: The heterogeneity of schizophrenia mainly results from variations in clinical expressions of the disease, such as age at onset, gender differences in onset of illness, symptoms and response to antipsychotic treatment. Enhanced sensitisation of dopamine pathways in males, having consistently an earlier onset, might be implicated as disease modifiers for schizophrenia in males. Methods: In this study, we performed a case (n = 87)-control (n = 100) association study between the DBH5'-ins/del and DBH-444g/a polymorphisms of the DBH gene and also compared the level of psychotic symptoms between patients with different DBH genotypes/haplotypes with respect to antipsychotic therapeutic response and gender difference. Results: No significant differences between allele and genotype and haplotype frequencies at either groups (p < 0.05). When the age is considered in patient group, a significant difference was observed between patients with ID genotype and with II genotype (p = 0.018). Patients with ID genotype have been diagnosed as schizophrenics in early ages when compared to II genotype carriers. We also found a significant difference between II and ID genotype (p = 0.007) when the gender had taken into account, showing that the ID genotype carriers had an early onset to schizophrenia. Conclusions: This association was more significant in male schizophrenia patients than females. Thus, this finding may constitute a novel biological support for the prior finding that onset of schizophrenia varies with gender. The results also showed that critical genetic vulnerability may be associated with the presence or absence of the ID genotype of DBH5'-ins/del.
Açıklama
Erdal, Mehmet Emin/0000-0002-6191-2930; barlas, ibrahim omer/0000-0002-2645-4487; Ankarali, Handan Camdeviren/0000-0002-3613-0523; Algul, Ayhan/0000-0002-6570-7141
WOS: 000304344800009
PubMed: 26953012
WOS: 000304344800009
PubMed: 26953012
Anahtar Kelimeler
age at onset, dopamine beta hydroxylase, male gender, polymorphism, schizophrenia
Kaynak
Acta Neuropsychiatrica
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
24
Sayı
3
