Prevention of Pleural Adhesions Using a Membrane Containing Polyethylene Glycol in Rats

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dc.contributor.authorKaraçam, Volkan
dc.contributor.authorÖnen, Ahmet
dc.contributor.authorŞanlı, Aydın
dc.contributor.authorGürel, Duygu
dc.contributor.authorKargı, Aydanur
dc.contributor.authorKarapolat, Sami
dc.contributor.authorÖzdemir, Nezih
dc.date.accessioned2020-04-30T23:21:37Z
dc.date.available2020-04-30T23:21:37Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000292520000005en_US
dc.descriptionPubMed: 21698057en_US
dc.description.abstractBackground: Recurrent thoracotomies regardless of the cause are not a rare occurrence. However, each thoracotomy results in adhesion to some extent. This adhesions increase morbidity and mortality presents a significant inconvenience for surgeons and prolongs the length of operations. Objective: We investigated the efficacy of Prevadh (R), an anti-adhesion agent to prevent intrapleural adesions following thoracotomy in a rat model. Methods: Twenty male adult Wistar Albino rats were divided into a sham group (Group A, n = 4), a control group (Group B, n = 8), and a study group (Group C, n = 8). Only left thoracotomy was performed in Group A. Group B underwent left thoracotomy, induction of adhesion, and 1 ml saline solution was administered to the thoracic cavity. However, in Group C underwent left thoracotomy, induction of adhesion, and Prevadh (R) was placed between the pleura and the lung. The rats were sacrificed on day 21, and adhesions were analyzed using both macroscopic and histopathological methods. The results were statistically analyzed. A value of P<0.05 was considered statistically significant. Results: Mean lengths of adhesion differed statistically significantly among all three groups, while mean intensity of adhesion differed between Group A and Group B, and between Group B and Group C (P>0.05). There was also a statistically significant difference between Group A and Group C in mesothelium proliferation score (P>0.05). No statistically significant differences were found among the groups in terms of pleural thickness, macrophage and mononuclear cell infiltration (P>0.05). Conclusions: Prevadh (R) was shown in a rat model to effectively prevent post-thoracotomy adhesions.en_US
dc.identifier.doi10.7150/ijms.8.380en_US
dc.identifier.endpage386en_US
dc.identifier.issn1449-1907
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage380en_US
dc.identifier.urihttps://doi.org/10.7150/ijms.8.380
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4222
dc.identifier.volume8en_US
dc.identifier.wosWOS:000292520000005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIvyspring Int Publen_US
dc.relation.ispartofInternational Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThoracic Surgeryen_US
dc.subjectThoracotomyen_US
dc.subjectTissue Adhesionsen_US
dc.subjectPolyethylene Glycolsen_US
dc.titlePrevention of Pleural Adhesions Using a Membrane Containing Polyethylene Glycol in Ratsen_US
dc.typeArticleen_US

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