Maternal and umbilical cord copeptin levels in pregnancies complicated by fetal growth restriction

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dc.contributor.authorBülbül, Gül Alkan
dc.contributor.authorKumru, Selahattin
dc.contributor.authorErol, Onur
dc.contributor.authorİsenlik, Bekir Sıtkı
dc.contributor.authorÖzdemir, Özgür
dc.contributor.authorÇağlar, Mete
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2020-04-30T23:19:05Z
dc.date.available2020-04-30T23:19:05Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666; Erol, Onur/0000-0002-7411-1200; KALAYCI, Mehmet/0000-0001-9122-9289en_US
dc.descriptionWOS: 000360436500006en_US
dc.descriptionPubMed: 25133666en_US
dc.description.abstractObjective: The aim of this study was to compare maternal and fetal serum copeptin concentrations in pregnancies complicated by isolated fetal growth restriction (FGR), and uncomplicated pregnancies, and to investigate relationships between copeptin levels and clinical parameters. Methods: Maternal and fetal serum copeptin levels were measured in 21 women with pregnancies complicated by isolated FGR and 20 women with normal pregnancies (control group). Doppler assessment of the uterine and umbilical arteries was performed in each patient. Results: Maternal serum copeptin levels were significantly higher in women with isolated FGR compared to controls (p = 0.042). In addition, maternal copeptin levels were inversely correlated with the uterine artery pulsatility and resistance indices and positively correlated with neonatal birth weight. Umbilical vein copeptin levels were significantly increased in neonates with adverse outcomes (p = 0.001). Conclusions: Increased maternal copeptin concentration may reflect a response to stress, thus serving as a compensatory mechanism in pregnancies complicated by FGR.en_US
dc.identifier.doi10.3109/14767058.2014.951622en_US
dc.identifier.endpage1284en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1278en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2014.951622
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3642
dc.identifier.volume28en_US
dc.identifier.wosWOS:000360436500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopeptinen_US
dc.subjectDoppler velocimetryen_US
dc.subjectfetal growth restrictionen_US
dc.subjectneonatal outcomeen_US
dc.subjectpregnancyen_US
dc.titleMaternal and umbilical cord copeptin levels in pregnancies complicated by fetal growth restrictionen_US
dc.typeArticleen_US

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