The effects of CDP-choline treatment in Amanita phalloides mushroom toxicosis

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dc.authoridCoskun, Nuri Cenk/0000-0002-9202-1145en_US
dc.authorscopusid57218685199en_US
dc.authorscopusid57212619932en_US
dc.authorwosidCoskun, Nuri Cenk/B-2156-2018en_US
dc.contributor.authorCoskun, Nuri Cenk
dc.contributor.authorBuyucek, Seyma
dc.date.accessioned2024-08-23T16:04:32Z
dc.date.available2024-08-23T16:04:32Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAmanita phalloides poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on Amanita phalloides mushroom poisoning cases. The extract of the Amanita phalloides mushroom was taken and intraperitoneally administered to male Wistar Albino rats at a dose of 0.3 g/kg. In the experiment phase, the rats were divided into three groups of CDP-choline treatment according to the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg, and one control group was administered a 1 ml/kg dose of 0.9% isotonic NaCl solution. The treatments were then administered intraperitoneally at the 2nd hour, and at the 6th hour, the rats were sacrificed. The degree of damage in the liver and kidney tissues of the rats was evaluated histopathologically. It was concluded that CDP-choline reduced or prevented the damage that occurred in the liver significantly and dose-dependently in the toxicosis picture caused by Amanita phalloides , and it showed a tendency to lower or prevent the damage in the kidney, albeit not significantly.en_US
dc.identifier.doi10.1016/j.toxicon.2024.107688
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid38484849en_US
dc.identifier.scopus2-s2.0-85187648548en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2024.107688
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14253
dc.identifier.volume241en_US
dc.identifier.wosWOS:001224900300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmanita phalloidesen_US
dc.subjectCDP-cholineen_US
dc.subjectRaten_US
dc.subjectTreatmenten_US
dc.subjectToxicosisen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectAdverse Reactionsen_US
dc.subjectAlpha-Amanitinen_US
dc.subjectThioctic Aciden_US
dc.subjectTissue-Injuryen_US
dc.subjectParacetamolen_US
dc.subjectPreventionen_US
dc.subjectAmatoxinsen_US
dc.subjectRaten_US
dc.subjectPhosphatidylcholineen_US
dc.titleThe effects of CDP-choline treatment in Amanita phalloides mushroom toxicosisen_US
dc.typeArticleen_US

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