The effects of CDP-choline treatment in Amanita phalloides mushroom toxicosis
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amanita phalloides poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on Amanita phalloides mushroom poisoning cases. The extract of the Amanita phalloides mushroom was taken and intraperitoneally administered to male Wistar Albino rats at a dose of 0.3 g/kg. In the experiment phase, the rats were divided into three groups of CDP-choline treatment according to the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg, and one control group was administered a 1 ml/kg dose of 0.9% isotonic NaCl solution. The treatments were then administered intraperitoneally at the 2nd hour, and at the 6th hour, the rats were sacrificed. The degree of damage in the liver and kidney tissues of the rats was evaluated histopathologically. It was concluded that CDP-choline reduced or prevented the damage that occurred in the liver significantly and dose-dependently in the toxicosis picture caused by Amanita phalloides , and it showed a tendency to lower or prevent the damage in the kidney, albeit not significantly.
Açıklama
Anahtar Kelimeler
Amanita phalloides, CDP-choline, Rat, Treatment, Toxicosis, N-Acetylcysteine, Adverse Reactions, Alpha-Amanitin, Thioctic Acid, Tissue-Injury, Paracetamol, Prevention, Amatoxins, Rat, Phosphatidylcholine
Kaynak
Toxicon
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
241
