Protective effect of oxymatrine against renal ischemia/reperfusion injury in rats

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dc.contributor.authorHülya, Öztürk
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorYılmaz, Fahri
dc.date.accessioned2020-04-30T23:21:51Z
dc.date.available2020-04-30T23:21:51Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCETINKAYA, Ayhan/0000-0002-8212-7149en_US
dc.descriptionWOS: 000401303100006en_US
dc.descriptionPubMed: 28471232en_US
dc.description.abstractBACKGROUND: Renal ischemia/reperfusion (I/R) injury is a common cause of acute kidney injury. The pathologic mechanisms underlying renal I/R injury are complicated, involving reactive oxygen species, necrosis, cell apoptosis, and inflammation, but the exact mechanisms remain unclear. OBJECTIVES: This study aimed to investigate the effect of oxymatrine (OMT) on renal I/R injury and its underlying mechanism. METHODS: Thirty male Sprague Dawley rats were randomly allocated to three groups (n = 10): the sham-control group, the renal I/R-untreated (I/R-untreated) group, and the I/R-OMT group. Renal I/R injury were induced by clamping the left renal artery for 45 min followed by 24 h of reperfusion. At 10 min before reperfusion, the rats in the I/R-OMT-treated group rats received an intravenous injection of 40 mg/kg OMT. Renal function and histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. RESULTS: Oxymatrine pretreatment significantly decreased the level of renal dysfunction, attenuated the renal histological changes, the levels of reactive oxygen species production in renal tissue upon I/R. Additionally, OMT pretreatment could further activate the serum antioxidant enzyme activities. CONCLUSION: The beneficial effects of OMT were likely mediated by the inhibition of lipid peroxidation and the increase in endogenous antioxidant activity. The results of this study indicate that oxymatrine may represent a potent anti-oxidant drug to protect the kidney against I/R injury (Fig. 5, Ref. 29). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific Research Projects Unitof Abant Izzet Baysal UniversityAbant Izzet Baysal Universityen_US
dc.description.sponsorshipThis work was supported by "Scientific Research Projects Unit"of Abant Izzet Baysal University.en_US
dc.identifier.doi10.4149/BLL_2017_043en_US
dc.identifier.endpage222en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_043
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4261
dc.identifier.volume118en_US
dc.identifier.wosWOS:000401303100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectoxymatrineen_US
dc.subjectrenal ischemia/reperfusionen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.titleProtective effect of oxymatrine against renal ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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