Argyrophilic nucleolar organizing region associated protein synthesis in hair root cells of humans at different developmental stages and sex
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Date
2013
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Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Argyrophilic nucleolar organizing region (AgNORs) associated proteins are important for cell proliferation and various diseases. We investigated AgNOR protein synthesis in hair root cells of males and females at different ages using two-dimensional image analysis. Experiments were performed on 58 healthy male and 24 healthy female volunteers in three groups according to age and sex. Hair root cells obtained from hair follicles were stained with silver. Total AgNOR number/total nuclear number (TAN/TNN) and total AgNOR area/nuclear area (TAA/NA) for each nucleus were analyzed. The only significant difference was observed in TAA/NA values for males and females from 6 to 12 years old. We suggest that the difference is due to high NOR activity caused by increased growth hormone production in hair root cells.
Description
WOS: 000321904800007
PubMed: 23480229
PubMed: 23480229
Keywords
AgNORs, developmental stage, hair root, rRNA
Journal or Series
Biotechnic & Histochemistry
WoS Q Value
Q4
Scopus Q Value
Q2
Volume
88
Issue
5
