Serum levels of visfatin, resistin and adiponectin in patients with psoriatic arthritis and associations with disease severity

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dc.contributor.authorDikbaş, Oğuz
dc.contributor.authorTosun, Mehmet
dc.contributor.authorBes, Cemal
dc.contributor.authorTönük, Şükrü Burak
dc.contributor.authorAkşehirli, Özge Yılmaz
dc.contributor.authorSoy, Mehmet
dc.date.accessioned2020-04-30T23:31:53Z
dc.date.available2020-04-30T23:31:53Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionSOY, MEHMET/0000-0003-1710-7018; Tonuk, Sukru Burak/0000-0003-0290-9341en_US
dc.descriptionWOS: 000383531000007en_US
dc.descriptionPubMed: 25196858en_US
dc.description.abstractAim: Psoriatic arthritis (PsA) is an inflammatory form of arthritis typically associated with psoriasis and/or psoriatic nail disease. Adipocytokines were once thought to influence development of (only) insulin resistance and diabetes mellitus. However, it is now clear that adipocytokines play important roles in development of the inflammation associated with either autoimmune or auto-inflammatory disorders. In the present study, we measured changes in the serum levels of adiponectin, resistin and visfatin, and the associations of such changes with the extent of disease activity and insulin resistance in PsA patients. Material and methods: A total of 67 subjects (28 with PsA and 39 healthy controls) without hypertension or diabetes mellitus were enrolled. Adiponectin, resistin and visfatin levels, and the extent of insulin resistance (assayed using the homeostasis model [HOMA-IR]), were measured in all subjects. Assessment of PsA disease activity was done with the Disease Activity Index for Psoriatic Arthritis (DAPSA). Results: Psoriatic arthritis patients had considerably higher serum levels of adiponectin, resistin and visfatin than did healthy controls (all P < 0.05). In the logistic regression analysis, the following variables may contribute to complex pathogenesis of PsA: adiponectin (P = 0.001, OR = 3.1, 95% CI = 1.6-6.0), resistin (P = 006, OR = 1.8, 95% CI = 1.2-2.9) and visfatin (P = 0.031, OR = 3.9, 95% CI = 1.1-13.9). In contrast, we have not detected any correlation between DAPSA and adipocytokine serum levels (P > 0.05). Conclusion: There is no correlation between adipocytokines and disease activity. Although serum adiponectin, resistin and visfatin levels are higher in patients with PsA, pathophysiological significance of the result has to be evaluated with more extensive studies.en_US
dc.description.sponsorshipScientific Research Project Unit of Abant Izzet Baysal UniversityAbant Izzet Baysal University [2012.08.03.566]en_US
dc.description.sponsorshipThe technical assistance of Sengul Gunduz is greatly appreciated. This research has been supported by Scientific Research Project Unit of Abant Izzet Baysal University (Project Number: 2012.08.03.566). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/PhFsI7.en_US
dc.identifier.doi10.1111/1756-185X.12444en_US
dc.identifier.endpage677en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage672en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12444
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4514
dc.identifier.volume19en_US
dc.identifier.wosWOS:000383531000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadiponectinen_US
dc.subjectinsulin resistanceen_US
dc.subjectpsoriatic arthritisen_US
dc.subjectresistinen_US
dc.subjectvisfatinen_US
dc.titleSerum levels of visfatin, resistin and adiponectin in patients with psoriatic arthritis and associations with disease severityen_US
dc.typeArticleen_US

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