Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

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dc.authorid
dc.contributor.authorNisari, Mustafa
dc.contributor.authorEröz, Recep
dc.date.accessioned2021-12-01T18:23:00Z
dc.date.available2021-12-01T18:23:00Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractBackground/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinomaderivate from colon cancer (Caco-2 cell).Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as controland different capsaicin exposed doses (25uµ, 50uµ, and 75uµ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA)were calculated.Results: A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ)(P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.001) and between capsaicin (25uµ) and capsaicin (75uµ) (P = 0.000)for TAA/NA. Also, there were significant differences between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin(75uµ) (P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.000) and between capsaicin (25uµ) and capsaicin (75uµ) (P= 0.000) for mean AgNOR number.Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations areimportant for the most reliable treatment.en_US
dc.identifier.doi10.3906/sag-2003-251
dc.identifier.endpage1081en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid32490651en_US
dc.identifier.scopus2-s2.0-85090725320en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1076en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2003-251
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVME56UXpNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9616
dc.identifier.volume50en_US
dc.identifier.wosWOS:000613005100056en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleDoes capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNORen_US
dc.typeArticleen_US

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