Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis

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dc.contributor.authorSezgin, Melek
dc.contributor.authorBarlas, İbrahim Ömer
dc.contributor.authorYıldır, Seyfi
dc.contributor.authorTürköz, Gözde
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorŞahin, Günşah
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2020-04-30T22:39:32Z
dc.date.available2020-04-30T22:39:32Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionbarlas, ibrahim omer/0000-0002-2645-4487; Ankarali, Handan Camdeviren/0000-0002-3613-0523; Erdal, Mehmet Emin/0000-0002-6191-2930; Sahin, Gunsah/0000-0002-4215-6957en_US
dc.descriptionWOS: 000322120400017en_US
dc.descriptionPubMed: 23392773en_US
dc.description.abstractTo investigate the associations between Fas and FasL gene polymorphisms and susceptibility to knee osteoarthritis. Genomic DNA was obtained from 146 patients with knee osteoarthritis and 102 healthy controls. Genotype distributions and allelic frequencies of four polymorphisms of Fas (-670 G > A rs1800682, -1377 G > A rs2234767) and FasL (IVS2nt-124 A > G rs5030772, -844 T > C rs763110) genes were compared between the groups. Thereafter, this association was investigated between patients and controls of the same sex. There were significant differences between patients with knee osteoarthritis and controls regarding the genotype distributions and allelic frequencies of Fas-1377 G > A polymorphism (P = 0.0001 and P = 0.005, respectively). The Fas-1377 GG genotype and G allele were significantly more frequent in patients with knee osteoarthritis than in controls. Genotype distributions and allelic frequencies of Fas-670 G > A, FasL-844 T > C, and FasL IVS2nt-124 A > G polymorphisms did not differ between the groups (P > 0.05). However, there were no significant differences between patients and controls of the same sex (P > 0.05). These findings suggest that the Fas-1377 G > A polymorphism in the Fas gene related with apoptosis may contribute to susceptibility to knee osteoarthritis in the Turkish population. There is a need for further studies to evaluate the role of apoptosis in large cohorts.en_US
dc.identifier.doi10.1007/s00296-013-2688-1en_US
dc.identifier.endpage2043en_US
dc.identifier.issn0172-8172
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2039en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-013-2688-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2753
dc.identifier.volume33en_US
dc.identifier.wosWOS:000322120400017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectFasen_US
dc.subjectFas liganden_US
dc.subjectGene polymorphismen_US
dc.subjectOsteoarthritisen_US
dc.titleApoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritisen_US
dc.typeArticleen_US

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