The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study

Basit Öğe Kaydı
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorKılınç, Erkan
dc.contributor.authorBeyazçiçek, Özge
dc.contributor.authorÖzkan, Kayhan
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-04-30T23:33:09Z
dc.date.available2020-04-30T23:33:09Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCETINKAYA, Ayhan/0000-0002-8212-7149; Kilinc, Erkan/0000-0001-9261-2634; ankarali, seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000450536200017en_US
dc.description.abstractObjective: Rose oil (from Rosa damascene) has several effects which are analgesic, antispasmodic, antioxidant and neuroprotective role. Its antiepileptic effect has not been yet studied enough. In the present study, it was aimed to investigate acute effects of rose oil on the epileptiform activity in penicillin-induced epilepsy model in rats. Methods: Forty-two male Wistar rats weighing 230 to 260 g were divided into six groups with seven rats in each group. Control (+Penicillin), RO alone, Diazepam, and different doses of Rose oil including 100, 500 and 1000 mg/kg. Rats were pretreated with different doses of RO 30 min prior to penicillin treatment. Electrocorticogram recordings were taken from each animal for 2 hours after penicillin treatment. Results: Only the dose of 100 mg/kg of rose oil reduced significantly epileptic spike-wave frequency of epileptiform activity. However, comparing in terms of latency and spike-wave amplitude of epileptiform activity, there were no significant difference between the groups. Conclusions: In conclusion, acute administration of rose oil reduces spike-wave frequency of penicillin-induced epileptiform activity in rats. Therefore, these findings indicate that rose oil has antiepileptic effects.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2014.04.01.241]en_US
dc.description.sponsorshipThis study received grant support from Duzce University Research Fund. The project number: 2014.04.01.241.en_US
dc.identifier.doi10.18521/ktd.427781en_US
dc.identifier.endpage368en_US
dc.identifier.issn1309-3878
dc.identifier.issue3en_US
dc.identifier.startpage360en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.427781
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4906
dc.identifier.volume10en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRose Oilen_US
dc.subjectEpileptiform Activityen_US
dc.subjectEpilepsyen_US
dc.subjectElectrocorticographyen_US
dc.titleThe Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
4906.pdf
Boyut:
630.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Konuralp Tip Dergisi Koleksiyonu
Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu