Regulating the Regulators in Attention-Deficit/Hyperactivity Disorder: A Genetic Association Study of microRNA Biogenesis Pathways

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dc.contributor.authorKarakaş, Ümit
dc.contributor.authorAy, Özlem İzci
dc.contributor.authorAy, Mustafa Ertan
dc.contributor.authorWang, Wei
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorÇevik, Kenan
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2020-04-30T23:31:35Z
dc.date.available2020-04-30T23:31:35Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionErdal, Mehmet Emin/0000-0002-6191-2930; Ay, Mustafa Ertan/0000-0002-6152-7450;en_US
dc.descriptionWOS: 000403548500006en_US
dc.descriptionPubMed: 28557556en_US
dc.description.abstractAttention-deficit/ hyperactivity disorder (ADHD) is one of the most prevalent complex psychiatric disorders in children as well as adults. ADHD impacts not only the affected individuals but also their families and social and professional networks. The clinical and diagnostic criteria for ADHD remain imprecise, in part, due to lack of robust biomarkers. ADHD comprises multiple subsets of diseases that present a shared set of downstream clinical findings, while displaying extensive molecular heterogeneity. This calls for innovation in diagnostic strategies that can help establish an ADHD diagnosis unequivocally as well as guiding precision medicine in this common mental health disorder. No study has examined, to the best of our knowledge, the upstream regulation of miRNAs that impact the downstream final ADHD phenotype. The latter focus on putative genetic biomarkers that regulate the regulators and can be tested empirically, for example, through genetic association analyses of the biogenesis pathways for miRNAs that impact the ADHD phenotype. Hence, we report here polymorphic variation in 10 miRNA biogenesis pathway candidate genes, including RNASEN, DGCR8, XPO5, RAN, DICER1, TARBP2, AGO1, AGO2, GEMIN3, and GEMIN4, in a large sample from the Eastern Mediterranean region (N= 355; 191 cases and 164 controls). We found that AGO1 rs595961 was significantly associated with ADHD susceptibility (p < 0.05). While polymorphic variation in other miRNA biogenesis pathway genes did not display a significant association in the present sample, the observations reported herein on miRNA biogenesis variation offer a new avenue of research for innovation in biomarker discovery concerning ADHD and other complex psychiatric diseases with major global health burden.en_US
dc.description.sponsorshipBAP-SBE TTB (UK) from Mersin University Scientific Research Projects Department [2011-3 YL]en_US
dc.description.sponsorshipThis study was supported as the research grant BAP-SBE TTB (UK) 2011-3 YL from Mersin University Scientific Research Projects Department. The authors thank Ayse Nur Inci Kenar, Hasan Herken, and Asena Ayca Ozdemir for helpful discussions.en_US
dc.identifier.doi10.1089/omi.2017.0048en_US
dc.identifier.endpage358en_US
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage352en_US
dc.identifier.urihttps://doi.org/10.1089/omi.2017.0048
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4335
dc.identifier.volume21en_US
dc.identifier.wosWOS:000403548500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofOmics-A Journal Of Integrative Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADHDen_US
dc.subjectbiomarkersen_US
dc.subjectdiagnostics innovationen_US
dc.subjectmiRNA biogenesis pathwaysen_US
dc.subjectpsychiatric geneticsen_US
dc.titleRegulating the Regulators in Attention-Deficit/Hyperactivity Disorder: A Genetic Association Study of microRNA Biogenesis Pathwaysen_US
dc.typeArticleen_US

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