Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice

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dc.contributor.authorKısmalı, Görkem
dc.contributor.authorÜner, Aykut Göktürk
dc.contributor.authorMeral, Öğünç
dc.contributor.authorAlpay, Merve
dc.contributor.authorSalmanoğlu, Berrin
dc.contributor.authorÇakır, Dilek Ülker
dc.contributor.authorSel, Tevhide
dc.date.accessioned2020-04-30T23:20:27Z
dc.date.available2020-04-30T23:20:27Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionSALMANOGLU, BERRIN/0000-0003-4344-5782; Meral, Ogunc/0000-0001-8813-4991en_US
dc.descriptionWOS: 000484847800005en_US
dc.description.abstractNatural products and anti-inflammatory agents including cyclooxygenase-2 (COX-2) inhibitors which is a type of nonsteroidal anti-inflammatory drugs (NSAIDs) are highly considerable interest for the prevention of carcinogenesis. The objective of this study is to evaluate the oxidative status of colitis-associated cancer induced by azoxymethane (AOM)/dextran sulfate sodium (DSS), and the effects of COX-2 inhibitor in mice. Totally 40 mice were randomized and divided to four groups. All animals except control and Cox-2 inhibitor alone group received AOM/DSS to establish colitis-associated cancer model as reported elsewhere. COX-2 preferential inhibitor meloxicam was used to minimize side effects such as gastrointestinal hemorrhage. Meloxicam were used (5mg/kg, intraperitoneal) three times a week with meloxicam alone and AOM/DSS + meloxicam group. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Malondialdehyde (MDA) and Advanced Oxidation Protein Products (AOPP) which all of them are oxidative stress markers were measured by spectrophotometrically. The combination treatment of Meloxicam and AOM/DSS significantly increased (P<0.05) SOD activities in mice. GPx activities were found significantly increased (P<0.05) in Meloxicam and AOM/DSS combinations or alone. There were no differences between the control and treatment groups of MDA levels. AOPP levels of Meloxicam and AOM/DSS combination group were found higher than the other groups. Meloxicam and /or AOM/DSS treatment not caused lipid peroxidations, but increased the antioxidant enzymes and Advanced Oxidation Protein Products levels.en_US
dc.identifier.doi10.33988/auvfd.521040en_US
dc.identifier.endpage356en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.521040
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4010
dc.identifier.volume66en_US
dc.identifier.wosWOS:000484847800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzoxymethaneen_US
dc.subjectcolon canceren_US
dc.subjectCOX-2en_US
dc.subjectdextran sulfate sodiumen_US
dc.subjectoxidative stressen_US
dc.titleOxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in miceen_US
dc.typeArticleen_US

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