Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease

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dc.contributor.authorDeveci, Hacı Ahmet
dc.contributor.authorKükürt, Abdulsamed
dc.contributor.authorNur, Gökhan
dc.contributor.authorAlpay, Merve
dc.contributor.authorMerhan, Oğuz
dc.contributor.authorBozukluhan, Kadir
dc.contributor.authorKarapehlivan, Mahmut
dc.date.accessioned2020-04-30T23:31:53Z
dc.date.available2020-04-30T23:31:53Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionDEVECI, HACI AHMET/0000-0002-5613-0520;en_US
dc.descriptionWOS: 000427048800011en_US
dc.description.abstractThe aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2-4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P < 0.001) and HDL (P < 0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P < 0.001) compared to the healthy group. TOC was higher (P < 0.001) and TAC was lower (P < 0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection.en_US
dc.identifier.doi10.21521/mw.6078en_US
dc.identifier.endpage202en_US
dc.identifier.issn0025-8628
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.21521/mw.6078
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4516
dc.identifier.volume74en_US
dc.identifier.wosWOS:000427048800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Soc Veterinary Sciences Editorial Officeen_US
dc.relation.ispartofMedycyna Weterynaryjna-Veterinary Medicine-Science And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfoot and mouth diseaseen_US
dc.subjectparaoxonase activityen_US
dc.subjectsialic aciden_US
dc.subjectAwassi sheepen_US
dc.titleSerum paraoxonase activity and total sialic acid in sheep with foot and mouth diseaseen_US
dc.typeArticleen_US

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