Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Polish Soc Veterinary Sciences Editorial Office
Access Rights
info:eu-repo/semantics/openAccess
Abstract
The aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2-4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P < 0.001) and HDL (P < 0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P < 0.001) compared to the healthy group. TOC was higher (P < 0.001) and TAC was lower (P < 0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection.
Description
DEVECI, HACI AHMET/0000-0002-5613-0520;
WOS: 000427048800011
WOS: 000427048800011
Keywords
foot and mouth disease, paraoxonase activity, sialic acid, Awassi sheep
Journal or Series
Medycyna Weterynaryjna-Veterinary Medicine-Science And Practice
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
74
Issue
3
