The Effects of Erythropoietin on the Penicillin Induced Epileptiform Activity in Rats

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dc.contributor.authorBulur, Şule
dc.contributor.authorDemir, Şerif
dc.contributor.authorBahadır, Anzel
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorÖzmerdivenli, Recep
dc.contributor.authorBeyazçiçek, Ersin
dc.date.accessioned2020-04-30T23:33:21Z
dc.date.available2020-04-30T23:33:21Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000374311900008en_US
dc.description.abstractErythropoietin (Epo), a cytokine hormone produced in the kidney, promotes the formation of red blood cells in the bone marrow. The penicillin-induced epilepsy model is a commonly used experimental model for epilepsy research. The present study was conducted to elucidate the effect of Epo on penicillin-G (500 IU/2.5 mu l dose, intracortically (i.c)) -induced epileptiform activity in anesthetized adult Wistar-Albino rats (n=39). The animals were randomly divided into four groups as three treatment groups (groups 1-3) and a control group (no drug application). Rats in groups 1, 2 and 3 were intraperitoneally administered 2.000, 4.000 and 6.000 IU Epo/kg, respectively. The effects on penicillin G induced epilepsy were compared across groups using electrocorticography. Epo at 2.000 IU/kg did not cause a significant change (P>0.05) in epileptiform spike-wave activity (number/min) and/or amplitude (mu V) values, whereas the average number of spike-waves per minute and seizure severity decreased significantly in the 4.000 and 6.000 IU/kg Epo groups compared with the control (P<0.05). Consequently, the results of the present study show that administration of Epo has a dose-dependent antiepileptic effect in penicillin induced model of epilepsy in rats.en_US
dc.description.sponsorshipUniversity of Duzce, Scientific Research Projects Department, Duzce, TurkeyDuzce University [2010.04.01.039]en_US
dc.description.sponsorshipThis study was supported by a research project from the University of Duzce, Scientific Research Projects Department (Project Number: 2010.04.01.039 to Dr S. DEMIR), Duzce, Turkey.en_US
dc.identifier.doi10.9775/kvfd.2015.14142en_US
dc.identifier.endpage220en_US
dc.identifier.issn1300-6045
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2015.14142
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4952
dc.identifier.volume22en_US
dc.identifier.wosWOS:000374311900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErythropoietinen_US
dc.subjectElectrocorticographyen_US
dc.subjectEpilepsyen_US
dc.subjectPenicillinen_US
dc.subjectRaten_US
dc.titleThe Effects of Erythropoietin on the Penicillin Induced Epileptiform Activity in Ratsen_US
dc.typeArticleen_US

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