Outcomes of random start versus clomiphene citrate and gonadotropin cycles in occult premature ovarian insufficiency patients, refusing oocyte donation: a retrospective cohort study

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dc.contributor.authorHatırnaz, Şafak
dc.contributor.authorBaşbuğ, Alper
dc.contributor.authorAkarsu, Süleyman
dc.contributor.authorHatırnaz, Ebru
dc.contributor.authorDemirci, Hakan
dc.contributor.authorDahan, Michael H.
dc.date.accessioned2020-04-30T23:20:26Z
dc.date.available2020-04-30T23:20:26Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionHatirnaz, Safak/0000-0001-8859-0639; Dahan, Michael/0000-0002-8121-7708en_US
dc.descriptionWOS: 000452225200009en_US
dc.descriptionPubMed: 29847194en_US
dc.description.abstractThe aim of this study is to present the clinical outcomes of a random start, a spontaneous folliculogenesis protocol versus Clomiphene Citrate and Gonadotropin treatment in women with occult premature ovarian insufficiency. Women underwent treatment between 1 February 2009, and 30 May 2016. 41 women were treated with the random start protocol while 48 cases received ovarian stimulation with clomiphene and gonadotropins. All included cases met the criteria of 4 months of oligo-ovulation, follicular-stimulating hormone levels over 30 IU/L and anti-Mullerian hormone levels below 0.30 ng/mL. The random start protocol involved following the subjects for up to 6 months until spontaneous folliculogenesis occurred. The mean number of oocytes collected, mature oocytes, fertilized oocytes, and grade II embryos were significantly higher in the random start protocol (p < .05). The doses of gonadotropin administration and hCG were significantly lower in the random start protocol (p < .05). The clinical pregnancy and live birth rates were significantly higher in the random start protocol (p < .05). Likely stimulation is of little benefit in women with occult premature ovarian insufficiency. Observation while waiting for spontaneous folliculogenesis results in better outcomes, and less oocyte collections.en_US
dc.identifier.doi10.1080/09513590.2018.1473361en_US
dc.identifier.endpage954en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage949en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2018.1473361
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4006
dc.identifier.volume34en_US
dc.identifier.wosWOS:000452225200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssisted reproductionen_US
dc.subjectclomiphene citrateen_US
dc.subjectfollicular wavesen_US
dc.subjectpremature ovarian insufficiencyen_US
dc.subjectrandom start protocolen_US
dc.titleOutcomes of random start versus clomiphene citrate and gonadotropin cycles in occult premature ovarian insufficiency patients, refusing oocyte donation: a retrospective cohort studyen_US
dc.typeArticleen_US

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