Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model

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dc.contributor.authorYıldız, Kartal Hakan
dc.contributor.authorGezen, Ferruh
dc.contributor.authorİş, Merih
dc.contributor.authorÇukur, Selma
dc.contributor.authorDöşoğlu, Murat
dc.date.accessioned2020-04-30T23:19:15Z
dc.date.available2020-04-30T23:19:15Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description8th Annual Meeting of the Spine-Society-of-Europe -- OCT 25-28, 2006 -- Istanbul, TURKEYen_US
dc.descriptionWOS: 000249404200031en_US
dc.descriptionPubMed: 17387523en_US
dc.description.abstractThis study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model. Thirty-two 2-year-old male Wistar albino rats, each weighing 400 +/- 50 g, were divided into four equal groups: sham, MMC, 5-FU, and CsA. Each rat underwent laminectomy at the L5-L6 lumbar level. Cotton pads (4 x 4 mm(2)) soaked with MMC (0.5 mg/ml), 5-FU (5 ml/mg), or CsA (5 mg/ml) were placed on the exposed dura for 5 min. Thirty days after surgery, the rats were killed and the epidural fibrosis, fibroblast density, inflammatory cell density, and arachnoid fibrosis were quantified. The epidural and arachnoid fibroses were reduced significantly in the treatment groups compared to the sham group. Fibroblast cell density and inflammatory cell density were decreased significantly in the MMC and 5-FU groups, but were similar in the sham and CsA groups. The decreased rate of epidural fibrosis was promising. Further studies in humans are needed to determine the short- and long-term complications of the agents used here.en_US
dc.description.sponsorshipSpine Soc Europeen_US
dc.identifier.doi10.1007/s00586-007-0344-8en_US
dc.identifier.endpage1530en_US
dc.identifier.issn0940-6719
dc.identifier.issn1432-0932
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1525en_US
dc.identifier.urihttps://doi.org/10.1007/s00586-007-0344-8
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3699
dc.identifier.volume16en_US
dc.identifier.wosWOS:000249404200031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Spine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectepidural fibrosisen_US
dc.subjectmitomycin Cen_US
dc.subject5-fluorouracilen_US
dc.subjectcyclosporine Aen_US
dc.titleMitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy modelen_US
dc.typeArticleen_US

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