Reconstruction of the urethral defects with autologous fascial tube graft in a rabbit model

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dc.contributor.authorSade, Çağrı
dc.contributor.authorUğurlu, Kemal
dc.contributor.authorÖzçelik, Derya
dc.contributor.authorHüthüt, İlkay
dc.contributor.authorÖzer, Kürşat
dc.contributor.authorÜstündağ, Nil
dc.contributor.authorBaş, Lütfü
dc.date.accessioned2020-04-30T23:31:34Z
dc.date.available2020-04-30T23:31:34Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionSaglam, Ibrahim/0000-0002-1706-4444en_US
dc.descriptionWOS: 000250783800014en_US
dc.descriptionPubMed: 17968471en_US
dc.description.abstractAim: To investigate the feasibility of the autologous fascia graft in urethra defect reconstruction. Methods: In 24 adult male rabbits, a standardized defect (17 mm) was created within the midportion of each urethra. Two-cm long fascial tube grafts were interposed between the cut ends of the urethra. Twenty-four rabbits were divided into 12 groups. At 0, 3, 10, 15, 21, 30, 45, 60, 90, 120, 150, and 180 days postoperatively, one group was killed. In the first four groups, rabbits were killed and specimens were obtained for histological examination. After 21 postoperative days, in the subsequent eight groups, retrograde urethrograms were carried out to evaluate urethral patency and caliber, then rabbits were killed and specimens were obtained. Results: In the histological study, advancement of the urethral transitional epithelium along scaffold provided by the fascial graft was determined. At the 30th day, the new urethra was completely covered with the transitional epithelium. Fistula formation was observed in two of 24 rabbits. In urethrograms, narrowing was determined in three of 16 rabbits. Conclusion: For segmental urethral reconstruction, fascial graft is a good urethral substitute because of its rapid epithelization capacity, low contraction degree and thinness. We therefore propose the use of fascial grafts for reconstruction of male-urethra defects in humans.en_US
dc.identifier.doi10.1111/j.1745-7262.2007.00271.xen_US
dc.identifier.endpage842en_US
dc.identifier.issn1008-682X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage835en_US
dc.identifier.urihttps://doi.org/10.1111/j.1745-7262.2007.00271.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4320
dc.identifier.volume9en_US
dc.identifier.wosWOS:000250783800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofAsian Journal Of Andrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecturethraen_US
dc.subjectdefecten_US
dc.subjectfasciaen_US
dc.subjectgraften_US
dc.subjectrecoristructionen_US
dc.titleReconstruction of the urethral defects with autologous fascial tube graft in a rabbit modelen_US
dc.typeArticleen_US

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