Early glutamine-enriched enteral feeding facilitates colonic anastomosis healing: Light microscopic and immunohistochemical evaluation

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dc.contributor.authorGüven, Aysel
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorGökpınar, İbrahim
dc.contributor.authorGürleyik, Emin
dc.contributor.authorÇam, Meryem
dc.date.accessioned2020-05-01T09:11:32Z
dc.date.available2020-05-01T09:11:32Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000245883500003en_US
dc.descriptionPubMed: 17346784en_US
dc.description.abstractProblems related to colonic anastomosis heating constitute the major morbidity in colorectal surgery. Patients without appropriate nutritional support are at higher risk of postsurgical complications, mainly due to reduced wound heating. Therefore, we investigated the effect of early and late postoperative total enteral. nutrition (TEN) and glutamine addition on colon anastomosis heating using tight microscopy and immunohistochemistry (IGF-I immunolabelling). In this study, 40 Wistar-albino rats underwent distal. left colonic transection and anastomosis. The rats were then divided into four groups given different diets: delayed total enteral. nutrition (dTEN; beginning 3 days postoperatively), delayed TEN with added glutamine (dTEN+ Glutamine), early TEN (eTEN; beginning within 6 h postoperatively), and early TEN with added glutamine (eTEN+Glutamine). Colon segments, including the anastomosis, were excised 7 days postoperatively and evaluated histopathologically for inflammation, mucosal heating, submucosal-muscular layer repair, the amounts of necrosis and vascularisation and immunohistochemically for IGF-I labelling. The inflammation and necrosis scores in the dTEN and dTEN+Glutamine groups were significantly greater than in the eTEN and eTEN+GLutamine groups. The IGF-I immunoreactivity increased in the eTEN, eTEN+Glutamine, and dTEN+Glutamine groups compared to dTEN (p<0.05). We concluded that early TEN and glutamine enrichment in the postoperative period improve anastomosis heating via IGF-I. (c) 2007 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2006.11.004en_US
dc.identifier.endpage129en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2006.11.004
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5650
dc.identifier.volume109en_US
dc.identifier.wosWOS:000245883500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolon anastomosisen_US
dc.subjectenteral nutritionen_US
dc.subjectglutamineen_US
dc.subjectIGF-Ien_US
dc.subjectwound healingen_US
dc.titleEarly glutamine-enriched enteral feeding facilitates colonic anastomosis healing: Light microscopic and immunohistochemical evaluationen_US
dc.typeArticleen_US

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