Does postoperative misoprostol use induce intestinal motility? A prospective randomised double-blind trial

Basit Öğe Kaydı
dc.contributor.authorDemirci, Fuat
dc.contributor.authorSomunkıran, Aslı
dc.contributor.authorGul, Özlem Kemik
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorÖzdemir, İsmail
dc.contributor.authorGül, Özgür Barış
dc.date.accessioned2020-05-01T09:11:29Z
dc.date.available2020-05-01T09:11:29Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000249480400013en_US
dc.descriptionPubMed: 17877601en_US
dc.description.abstractBackground: Misoprostol has been shown to increase colonic activity and decrease colonic transit time in chronic constipation patients. Aims: The aim of this prospective, randomised, double-blind study was to examine the effectiveness of rectally administered misoprostol on inducing intestinal motility after gynaecological surgery. Methods: Eighty women who underwent hysterectomy were divided randomly into three groups. Group A received misoprostol 200 mu g rectally while group B received 400 mu g rectal misoprostol after surgery before leaving the operating room. Patients in group C received no drugs. Bowel sounds in four quadrants were checked every hour and possible side-effects of misoprostol like nausea, vomiting, and distension were evaluated. The time interval between surgery and flatus pass and the need of analgesics were noted. Statistical analyses were done with Mann-Whitney U-test and chi(2) tests where available. Results: The time between surgery and presence of bowel sounds in four quadrants were similar in all groups (2.7 +/- 1.6, 2.9 +/- 1.2, 2.8 +/- 1.3 h, for groups A, B, and C, respectively). No difference was observed in flatus pass time. The incidence of nausea was significantly increased in group B compared to controls (P < 0.01). Additional analgesic need was significantly higher in groups A and B when compared to controls (P < 0.05 and P < 0.01, for groups A and B, respectively). Conclusion: Rectally administered misoprostol does not improve intestinal motility in the early postoperative period and thus, it is not effective in providing early oral food intake. On the contrary, it causes distention that requires additional analgesics and vomiting that naturally limits oral diet intake.en_US
dc.identifier.doi10.1111/j.1479-828X.2007.00767.xen_US
dc.identifier.endpage414en_US
dc.identifier.issn0004-8666
dc.identifier.issn1479-828X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage410en_US
dc.identifier.urihttps://doi.org/10.1111/j.1479-828X.2007.00767.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5619
dc.identifier.volume47en_US
dc.identifier.wosWOS:000249480400013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAustralian & New Zealand Journal Of Obstetrics & Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintestinal motilityen_US
dc.subjectmisoprostolen_US
dc.subjectnauseaen_US
dc.subjectpostoperativeen_US
dc.subjectprostaglandin E1en_US
dc.titleDoes postoperative misoprostol use induce intestinal motility? A prospective randomised double-blind trialen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5619.pdf
Boyut:
194.43 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu