Deleterious impacts of a 900-MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male rats

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dc.contributor.authorŞahin, Arzu
dc.contributor.authorAslan, Ali
dc.contributor.authorBaş, Orhan
dc.contributor.authorİkinci, Ayşe
dc.contributor.authorÖzyılmaz, Cansu
dc.contributor.authorSönmez, Osman Fikret
dc.contributor.authorOdacı, Ersan
dc.date.accessioned2020-05-01T09:11:17Z
dc.date.available2020-05-01T09:11:17Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000365050100024en_US
dc.descriptionPubMed: 26239913en_US
dc.description.abstractChildren are at potential risk due to their intense use of mobile phones. We examined 8-week-old rats because this age of the rats is comparable with the preadolescent period in humans. The number of pyramidal neurons in the cornu ammonis of the Sprague Dawley male rat (8-weeks old, weighing 180-250 g) hippocampus following exposure to a 900 MHz (MHz) electromagnetic field (EMF) were examined. The study consisted of control (CN-G), sham exposed (SHM-EG) and EMF exposed (EMF-EG) groups with 6 rats in each. The EMF-EG rats were exposed to 900 MHz EMF (1 h/day for 30 days) in an EMF jar. The SHM-EG rats were placed in the EMF jar but not exposed to the EMF (1 h/day for 30 days). The CN-G rats were not placed into the exposure jar and were not exposed to the EMF during the study period. All animals were sacrificed at the end of the experiment, and their brains were removed for histopathological and stereological analysis. The number of pyramidal neurons in the cornu ammonis of the hippocampus was estimated on Cresyl violet stained sections of the brain using the optical dissector counting technique. Histopathological evaluations were also performed on these sections. Histopathological observation showed abundant cells with abnormal, black or dark blue cytoplasm and shrunken morphology among the normal pyramidal neurons. The largest lateral ventricles were observed in the EMF-EG sections compared to those from the other groups. Stereological analyses showed that the total number of pyramidal neurons in the cornu ammonis of the EMF-EG rats was significantly lower than those in the CN-G (p<0.05) and the SHM-EG (p<0.05). In conclusion, our results suggest that pyramidal neuron loss and histopathological changes in the cornu ammonis of 8-week-old male rats may be due to the 900-MHz EMF exposure. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2015.07.042en_US
dc.identifier.endpage238en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2015.07.042
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5471
dc.identifier.volume1624en_US
dc.identifier.wosWOS:000365050100024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic fielden_US
dc.subjectCell phoneen_US
dc.subjectChildrenen_US
dc.subjectHippocampusen_US
dc.subjectPyramidal neuronen_US
dc.subjectMale raten_US
dc.titleDeleterious impacts of a 900-MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male ratsen_US
dc.typeArticleen_US

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