Erythropoietin accelerates fracture healing an experimental animal study

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dc.contributor.authorTürkeli, Erdinç
dc.contributor.authorUslu, Mustafa
dc.contributor.authorDoğan, Ali
dc.date.accessioned2020-04-30T13:32:26Z
dc.date.available2020-04-30T13:32:26Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The efficacy of erythropoietin (EPO) on wound healing has been shown before. There is limited data about the efficacy of EPO on fracture healing. In this study, the efficacy of EPO on closed forearm fracture healing is searched by an experimental model. Material and method: Twenty eight rats were picked randomly and divided into EPO and Control groups. On the first day, fracture was performed on the right ulna and radius of all rats. 500 U/kg daily low dose EPO was administered for each rat in EPO group and the same volume of isotonic sodium chloride solution was given intraperitoneally in the control group for five days. Seven rats from each group were sacrificed at the end of the first week; the others were sacrificed at the end of the third week. Results: At the end of the first week and third week, bone healing scores of EPO group is significantly higher than the control group according to the histological, clinic and radiologic analysis. Conclusion: EPO could have positive effects on healing of forearm fracture on rats in acute and subacute period. Low dose EPO may be a new protective agent against delayed union or nonunion in the risk population to go or not to go to surgical treatment. © 2012 Düzce Medical Journal.en_US
dc.identifier.endpage11en_US
dc.identifier.issn1307671X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/290
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythropoietin; Fracture healing; Raten_US
dc.titleErythropoietin accelerates fracture healing an experimental animal studyen_US
dc.title.alternativeEritropoetin kırık iyileşmesini hızlandırıyor deneysel hayvan çalışmasıen_US
dc.typeArticleen_US

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