Erythropoietin accelerates fracture healing an experimental animal study
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Dosyalar
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce University Medical School
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: The efficacy of erythropoietin (EPO) on wound healing has been shown before. There is limited data about the efficacy of EPO on fracture healing. In this study, the efficacy of EPO on closed forearm fracture healing is searched by an experimental model. Material and method: Twenty eight rats were picked randomly and divided into EPO and Control groups. On the first day, fracture was performed on the right ulna and radius of all rats. 500 U/kg daily low dose EPO was administered for each rat in EPO group and the same volume of isotonic sodium chloride solution was given intraperitoneally in the control group for five days. Seven rats from each group were sacrificed at the end of the first week; the others were sacrificed at the end of the third week. Results: At the end of the first week and third week, bone healing scores of EPO group is significantly higher than the control group according to the histological, clinic and radiologic analysis. Conclusion: EPO could have positive effects on healing of forearm fracture on rats in acute and subacute period. Low dose EPO may be a new protective agent against delayed union or nonunion in the risk population to go or not to go to surgical treatment. © 2012 Düzce Medical Journal.
Açıklama
Anahtar Kelimeler
Erythropoietin; Fracture healing; Rat
Kaynak
Duzce Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
16
Sayı
1
