Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method

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dc.contributor.authorTunca, Mustafa
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorYürekli, Aslan
dc.contributor.authorGöksel, Berk Alp
dc.contributor.authorÇiçek, Ali Fuat
dc.contributor.authorÇalışkan, Ercan
dc.date.accessioned2020-05-01T09:11:15Z
dc.date.available2020-05-01T09:11:15Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYurekli, Aslan/0000-0003-2812-2133en_US
dc.descriptionWOS: 000473301300002en_US
dc.descriptionPubMed: 31233167en_US
dc.description.abstractIntroduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. The objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. Methods: We introduced a novel technique to remove perichondrium using cryosurgery. Hypertrophic scars obtained with conventional surgery and cryosurgery were studied in a left-right comparison method. Comparative parameters included the histological structure of the scars and structural changes in the cartilage just beneath the scarring. Results: Cryosurgery produced similar scars in comparison to conventional surgery. Although statistically not significant (p = 0.16), the histological findings of cartilage damage were lower in the cryosurgery group (six out of 21) compared to the established model (10 out of 20). Conclusions: This study suggests that cryotherapy can be used for removal of perichondrium.en_US
dc.description.sponsorshipGulhane School of Medicine Research Grant committeeen_US
dc.description.sponsorshipThis study was financially supported by the Gulhane School of Medicine Research Grant committee and was conducted at the Animal Research Laboratory of the same institution.en_US
dc.identifier.doi10.15570/actaapa.2019.15en_US
dc.identifier.endpage59en_US
dc.identifier.issn1318-4458
dc.identifier.issn1581-2979
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.15570/actaapa.2019.15
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5421
dc.identifier.volume28en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDermatovenerological Soc Sloveniaen_US
dc.relation.ispartofActa Dermatovenerologica Alpina Pannonica Et Adriaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanimal modelen_US
dc.subjectcryotherapyen_US
dc.subjecthypertrophic scaren_US
dc.titleCryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified methoden_US
dc.typeArticleen_US

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