High serum homocysteine levels correlate with a decrease in the blood flow velocity of the ophthalmic artery in highway toll collectors

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dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorYüksel, Harun
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorYüksel, Hatice Kurt
dc.contributor.authorYazgan, Ömer
dc.contributor.authorBilgin, Cahit
dc.date.accessioned2020-05-01T12:10:22Z
dc.date.available2020-05-01T12:10:22Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; BILGIN, CAHIT/0000-0003-2213-5881en_US
dc.descriptionWOS: 000247655300005en_US
dc.descriptionPubMed: 17592212en_US
dc.description.abstractHighway workers, such as policemen, automotive service companies, and toll collectors, are placed at risk of the accelerated atherosclerotic process, since recent studies have suggested that exposure to exhaust particles and ambient air pollution increases carotid intima-media thickness and reduces ocular blood flow velocity. Therefore, we assessed the relationship between serum homocysteine, a potential parameter for atherosclerosis, and the ocular blood flow velocity and the resistivity index in highway toll collectors. The peak systolic and end diastolic flow velocities and the resistivity index were measured in 22 toll collectors and 24 control subjects by color Doppler ultrasonography. The resistivity index, which is an indirect measure of the atherosclerotic process, was calculated: resistivity index = (peak systolic velocity - end diastolic velocity)/peak systolic velocity. Serum homocysteine levels were determined by fluorometric high-performance liquid chromatography. In the highway toll collectors, the serum homocysteine level (14.4 +/- 4.8 mu mol/l; p < 0.005) and the resistivity index of the ophthalmic artery (0.741 +/- 0.015; p < 0.05) were higher and the ophthalmic blood flow velocity (33.0 < 3.0 cm/s; p < 0.001) was lower than those in the controls (10.6 +/- 3.1,mu mol/l; 0.728 +/- 0.023; 36.8 +/- 2.2 cm/s; respectively). There were significant correlations between the serum homocysteine level and ophthalmic artery resistivity index in both highway toll collectors (p < 0.001) and controls (p < 0.005). Exposure to exhaust particles might increase the serum homocysteine level, which in turn could lead to the decreased ocular blood flow and the increased resistivity index.en_US
dc.identifier.doi10.1620/tjem.212.247en_US
dc.identifier.endpage252en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.212.247
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6161
dc.identifier.volume212en_US
dc.identifier.wosWOS:000247655300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthomocysteineen_US
dc.subjectocular blood flowen_US
dc.subjecthighway toll collectorsen_US
dc.subjectcolor Doppler ultrasonographyen_US
dc.titleHigh serum homocysteine levels correlate with a decrease in the blood flow velocity of the ophthalmic artery in highway toll collectorsen_US
dc.typeArticleen_US

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