Thio-Schiff bases derived from 2,2 '-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cells

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dc.contributor.authorDalmaz, Aslıhan
dc.contributor.authorDurmuş, Sefa
dc.contributor.authorDülger, Görkem
dc.contributor.authorAlpay, Merve
dc.date.accessioned2023-07-26T11:54:08Z
dc.date.available2023-07-26T11:54:08Z
dc.date.issued2022
dc.departmentDÜ, Sağlık Bilimleri Enstitüsü, Doğal, Bitkisel Ürünler ve Kozmetik Ürünler Ana Bilim Dalıen_US
dc.description.abstractIn this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens. According to MIC results, the compound 2 was shown strong inhibitory activity against all the tested microorganisms compared to antibiotics. In addition, all the tested compounds showed different antiproliferative effects on the melanoma cell line (B16F10). Our synthesized dimeric disulfide-Schiff bases have shown significant various effects.en_US
dc.description.sponsorshipDuzce University Scientific Research Fund (BAP) [2014-05-03-259, 2015-05-03-354]en_US
dc.description.sponsorshipThis work is supported by the Duzce University Scientific Research Fund (BAP) (Project Number: 2014-05-03-259 and 2015-05-03-354).en_US
dc.identifier.doi10.55730/1300-0527.3414
dc.identifier.endpage+en_US
dc.identifier.issn1300-0527
dc.identifier.issue4en_US
dc.identifier.pmid37538759en_US
dc.identifier.scopus2-s2.0-85137385968en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1055en_US
dc.identifier.trdizinid1141979en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3414
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1141979
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12737
dc.identifier.volume46en_US
dc.identifier.wosWOS:000895319000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDalmaz, Aslıhan
dc.institutionauthorDurmuş, Sefa
dc.institutionauthorDülger, Görkem
dc.institutionauthorAlpay, Merve
dc.language.isoenen_US
dc.publisherScientific and Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectSchiff Base; Nanocatalyst Ceo2; Antimicrobial Activity; Cytotoxicity; Antiproliferative; Melanomaen_US
dc.subjectCrystal-Structure; Complexes; Disulfide; Nanoparticles; Ceria; Antibacterial; Derivatives; Anticancer; Copperen_US
dc.titleThio-Schiff bases derived from 2,2 '-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cellsen_US
dc.typeArticleen_US

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