Thio-Schiff bases derived from 2,2 '-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cells
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Scientific and Technological Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens. According to MIC results, the compound 2 was shown strong inhibitory activity against all the tested microorganisms compared to antibiotics. In addition, all the tested compounds showed different antiproliferative effects on the melanoma cell line (B16F10). Our synthesized dimeric disulfide-Schiff bases have shown significant various effects.
Açıklama
Anahtar Kelimeler
Schiff Base; Nanocatalyst Ceo2; Antimicrobial Activity; Cytotoxicity; Antiproliferative; Melanoma, Crystal-Structure; Complexes; Disulfide; Nanoparticles; Ceria; Antibacterial; Derivatives; Anticancer; Copper
Kaynak
Turkish Journal of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
46
Sayı
4
