CENTRAL NERVOUS SYSTEM COMPLICATIONS OF DIABETES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EXAMINATION

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dc.contributor.authorGüven, Aysel
dc.contributor.authorYavuz, Özlem
dc.contributor.authorÇam, Meryem
dc.contributor.authorÇomunoğlu, Cem
dc.contributor.authorSevinç, Özdemir
dc.date.accessioned2020-04-30T22:40:35Z
dc.date.available2020-04-30T22:40:35Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000268663600008en_US
dc.descriptionPubMed: 19922346en_US
dc.description.abstractDiabetes mellitus is a common, potentially serious metabolic disorder. Over the long term, diabetes leads to serious consequences in a number of tissues, especially those that are insulin insensitive (retina, neurons, kidneys). It also causes a variety of functional and structural disorders in the central and peripheral nervous systems. We investigated whether neurodegenerative changes were observable in the hippocampus, cortex, and cerebellum after 4 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of melatonin. Male Wistar rats (n = 32) were divided into four groups (n = 8 each): untreated controls, melatonin-treated controls, untreated diabetics, and melatonin-treated diabetics. Experimental diabetes was induced by a single dose of STZ (60 mg/kg, intraperitoneal (ip)). For 3 days before the administration of STZ, melatonin (200 mu g/kg/day, ip) was injected and continued for 4 weeks. Sections of hippocampus, cortex, and cerebellum were stained with hematoxylin and eosin and examined using light microscopy. In addition, brain tissues were examined immunohistochemically for the expression of glial and neuronal markers, including glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and heat shock protein-70 (HSP-70). No neurodegenerative changes were observed in the hippocampus, cortex, or cerebellum of the untreated diabetic group after 4 weeks compared with the other groups. We did not observe any change in GFAP, NSE, or HSP-70 immunostaining in the brain tissues of STZ-induced diabetic rats. In summary, after 4 weeks of STZ-induced diabetes in rats, no degenerative or immunohistochemical changes were detected in the hippocampus, cortex, or cerebellum.en_US
dc.identifier.doi10.1080/00207450902841723en_US
dc.identifier.endpage1169en_US
dc.identifier.issn0020-7454
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1155en_US
dc.identifier.urihttps://doi.org/10.1080/00207450902841723
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3016
dc.identifier.volume119en_US
dc.identifier.wosWOS:000268663600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjectglial fibrillary acidic proteinen_US
dc.subjectheat shock protein-70en_US
dc.subjectmelatoninen_US
dc.subjectneuron-specific enolaseen_US
dc.titleCENTRAL NERVOUS SYSTEM COMPLICATIONS OF DIABETES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EXAMINATIONen_US
dc.typeArticleen_US

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