Locomotor stimulation by acute propofol administration in rats: Role of the nitrergic system

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dc.contributor.authorTezcan, Aysu Hayriye
dc.contributor.authorÖzçetin, Ayşe
dc.contributor.authorÖzlü, Onur
dc.contributor.authorÇevreli, Burcu
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2020-04-30T23:18:58Z
dc.date.available2020-04-30T23:18:58Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionTezcan, Aysu Hayriye/0000-0001-7779-6965en_US
dc.descriptionWOS: 000362156100024en_US
dc.descriptionPubMed: 26398394en_US
dc.description.abstractBackground: The addictive potential of propofol has been scientifically discussed. Drugs' psychostimulant properties that can be assessed via measurements of locomotor activity are linked to their addictive properties. No studies that have investigated the effects of propofol on locomotor activity have been reported to date. The present study sought to investigate the effects and possible mechanisms of action of propofol on locomotor activity in rats. Methods: Adult male albino Wistar rats (250-330 g) were used as subjects. The locomotor activities of the rats were recorded for 30 min immediately following intraperitoneal administration of propofol (20 and 40 mg/kg), saline or vehicle (n = 8 for each group). NG-nitro arginine methyl ester (L-NAME, 15-60 mg/kg), a nitric oxide (NO) synthase inhibitor, and haloperidol (0.125-5 mg/kg), a non-specific dopamine receptor antagonist, were also administered to other groups of rats 30 min prior to the propofol (40 mg/kg) injections, and locomotor activity was recorded for 30 min immediately after propofol administration (n = 8 for each group). Results: Propofol produced significant increases in the locomotor activities of the rats in the first 5 min of the observation period [F(2,21) = 9.052; p <0.001]. L-NAME [F(4,35) = 3.112; p = 0.02] but not haloperidol [F(4,35) = 2.440; p = 0.067] pretreatment blocked the propofol-induced locomotor hyperactivity. L-NAME did not cause any significant change in locomotor activity in naive rats [F(2,21) = 0.569; p = 0.57]. Conclusions: Our results suggest that propofol might cause a short-term induction of locomotor activity in rats and that this effect might be related to nitrergic but not dopaminergic mechanisms. (C) 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z.o.o. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey Turkish Scientific and Technological Research Council (TUBITAK, Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [105S387, SBAG-3194]en_US
dc.description.sponsorshipThis study was partially funded and supported by the Scientific and Technological Research Council of Turkey Turkish Scientific and Technological Research Council (TUBITAK, Turkey; Project No: 105S387, SBAG-3194).en_US
dc.identifier.doi10.1016/j.pharep.2015.03.003en_US
dc.identifier.endpage985en_US
dc.identifier.issn1734-1140
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage980en_US
dc.identifier.urihttps://doi.org/10.1016/j.pharep.2015.03.003
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3604
dc.identifier.volume67en_US
dc.identifier.wosWOS:000362156100024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Acad Sciences Inst Pharmacologyen_US
dc.relation.ispartofPharmacological Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropofolen_US
dc.subjectLocomotor activityen_US
dc.subjectAbuse and dependenceen_US
dc.subjectNitric oxideen_US
dc.subjectRat(s)en_US
dc.titleLocomotor stimulation by acute propofol administration in rats: Role of the nitrergic systemen_US
dc.typeArticleen_US

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