Does melatonin alleviate cold preservation injury of the liver?

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dc.contributor.authorGünal, Ömer
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorAslaner, Arif
dc.contributor.authorYıldırım, Ümran
dc.date.accessioned2020-05-01T09:11:29Z
dc.date.available2020-05-01T09:11:29Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604;en_US
dc.descriptionWOS: 000280566800019en_US
dc.description.abstractAim: To investigate the effect of melatonin added to preservation solution on liver cold ischemia Materials and methods: Twenty male Wistar albino rats were divided equally into groups treated with University of Wisconsin (UW) solution with and without melatonin The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h Tissue malondialdehyde and heat shock protein (HSP 70) levels were also measured and a histological examination was performed at 48 h Results: Melatonin prevented enzyme elevation, induced heat shock protein (HSP 70), and decreased lipid peroxidation effectively in comparison to the control group (P < 0.05) The histological examination revealed that UW solution containing melatonin prevented Kupffer cell activation and inflammation significantly (P < 0.05) Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 hen_US
dc.description.sponsorshipAbant Izzet Baysal University Department of Scientific and Research Projects, Bolu, TurkeyAbant Izzet Baysal University [2005-07-01-236]en_US
dc.description.sponsorshipThis study was supported by Abant Izzet Baysal University Department of Scientific and Research Projects (2005-07-01-236), Bolu, Turkey.en_US
dc.identifier.doi10.3906/sag-0811-26en_US
dc.identifier.endpage470en_US
dc.identifier.issn1300-0144
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0811-26
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5616
dc.identifier.volume40en_US
dc.identifier.wosWOS:000280566800019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectcold preservationen_US
dc.subjectheat shock proteinen_US
dc.subjectliveren_US
dc.subjectmelatoninen_US
dc.subjectUniversity of Wisconsin solutionen_US
dc.titleDoes melatonin alleviate cold preservation injury of the liver?en_US
dc.typeArticleen_US

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