Apoptosis-associated Speck-like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patients

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dc.authoridKURT, FATIH/0000-0003-1975-6492en_US
dc.authoridKocabay, Kenan/0000-0002-4030-1145en_US
dc.contributor.authorKurt, Fatih
dc.contributor.authorEroz, Recep
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2024-08-23T16:03:51Z
dc.date.available2024-08-23T16:03:51Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Duzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF.Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined.Results: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly.Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.en_US
dc.identifier.doi10.18521/ktd.1162175
dc.identifier.endpage68en_US
dc.identifier.issn1309-3878
dc.identifier.issue1en_US
dc.identifier.startpage59en_US
dc.identifier.trdizinid1160766en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1162175
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1160766
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13944
dc.identifier.volume15en_US
dc.identifier.wosWOS:000957966500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFMFen_US
dc.subjectASCen_US
dc.subjectCXCL13en_US
dc.subjectTL-1aen_US
dc.subjectNitric-Oxideen_US
dc.subjectGeneen_US
dc.subjectMutationen_US
dc.subjectAmyloidosisen_US
dc.subjectDeletionen_US
dc.subjectRisken_US
dc.titleApoptosis-associated Speck-like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patientsen_US
dc.typeArticleen_US

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