Apoptosis-associated Speck-like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patients
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Duzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF.Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined.Results: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly.Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.
Açıklama
Anahtar Kelimeler
FMF, ASC, CXCL13, TL-1a, Nitric-Oxide, Gene, Mutation, Amyloidosis, Deletion, Risk
Kaynak
Konuralp Tıp Dergisi
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
15
Sayı
1
