Abuse potential assessment of propofol by its subjective effects after sedation

Basit Öğe Kaydı
dc.contributor.authorTezcan, Aysu Hayriye
dc.contributor.authorÖrnek, Dilşen Hatice
dc.contributor.authorÖzlü, Onur
dc.contributor.authorBaydar, Mustafa
dc.contributor.authorYavuz, Nurcan
dc.contributor.authorÖzaslan, Nihal Gökbulut
dc.contributor.authorKeske, Aylin
dc.date.accessioned2020-04-30T22:38:55Z
dc.date.available2020-04-30T22:38:55Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionTezcan, Aysu Hayriye/0000-0001-7779-6965; Ornek, Dilsen/0000-0002-3300-4839en_US
dc.descriptionWOS: 000346112400015en_US
dc.descriptionPubMed: 25674117en_US
dc.description.abstractObjective: In this study, we examined the euphoric effect of propofol and its high satisfaction ratio regarding its liability to be abused, particularly in painless procedures, such as colonoscopy. Methods: Fifty subjects aged between 18 and 65 years who fulfilled the criteria for ASA 1-2 and were prepared for colonoscopy were enrolled into this study. For intravenous sedation induction, 2 mg/kg propofol was used, and additional injections were administered according to BIS values. After colonoscopy, the subjects were taken to a recovery room and observed for 30 minutes. Patients were interviewed with the modified Brice questionnare regarding the incidence and the content of dreams. A 5-point Likert scale was used to classify their dreams, and the content of the dreams was also recorded. To assess the subjective effects of propofol, the patients were asked to use the Hall and Van der Castle emotion scale; their biological states were also assessed. The patients' feelings regarding propofol were each rated as absent or present. We used the Morphine-Benzedrine Group scale to measure the euphoric effects of propofol. At the end of the study, subjects scored their satisfaction on a five-point scale. Results: There were no statistically significant differences in sex age, weight, propofol dose, or satisfaction ratio (p > 0.05) in the groups, although male patients received a higher dose of propofol and had higher satisfaction ratio. Patients reported no residual after-effects. The incidence of dreaming was 42%. There was no statistically significant difference in dreaming between the sexes, but male patients had a higher dreaming ratio. Dreamers received higher propofol doses and had a higher satisfaction ratio (p > 0.05). All dreamers reported happy dreams regarding daily life, and their mean MBG score was 10.5. There was no correlation between MBG scores and propofol doses (r = -0.044, p = 0.761). Conclusions: We conclude that propofol functions as a reward; that patients enjoy its acute effects; and that no residual after-effects should arise. We suggest that propofol may carry potential for abuse, and further abuse liability testing is indicated.en_US
dc.identifier.endpage1252en_US
dc.identifier.issn1682-024X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1247en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2522
dc.identifier.volume30en_US
dc.identifier.wosWOS:000346112400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbuse potentialen_US
dc.subjectEuphoric effecten_US
dc.subjectPropofolen_US
dc.subjectSedationen_US
dc.titleAbuse potential assessment of propofol by its subjective effects after sedationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
2522.pdf
Boyut:
809.91 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu