The effect of extracorporeal shock wave lithotripsy on the rat spinal cord

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dc.contributor.authorKarataş, Anıl
dc.contributor.authorDöşoğlu, Murat
dc.contributor.authorZeyrek, T.
dc.contributor.authorKayıkçı, A.
dc.contributor.authorErol, Ali
dc.contributor.authorCan, Belgin
dc.date.accessioned2020-04-30T23:32:56Z
dc.date.available2020-04-30T23:32:56Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionCan, Belgin/0000-0002-0469-7998en_US
dc.descriptionWOS: 000258916000008en_US
dc.descriptionPubMed: 18414427en_US
dc.description.abstractStudy design: Experimental study. Objectives: To determine the effects of extracorporeal shock wave lithotripsy (ESWL) on the rat spinal cord. Methods: Animals were randomly divided into three groups. Groups 1 and 2 consisted of five rats each that underwent ESWL (2000 impulses at 15 kV and 2000 impulses at 18 kV, respectively) and group 3 contained five control rats (no shock wave treatment). ESWL-treated and control rats were compared with regard to light and electron microscopic findings of the adjacent spinal cord. Results: Gross neurological outcomes were normal in all groups. Light microscopic examination of group 1 showed extensive extravasation of red blood cells over all the interstitial spaces. Group 2 also had haemorrhagic areas and an irregular organization of axons in the white matter. Transmission electron microscopic examination of group 1 indicated extravasated red blood cells through the endothelium and swollen axoplasm, degenerated mitochondria, destruction of myelin sheaths and a slight increase in the number of lysosomes. Extravasated red blood cells were also seen in group 2. The axoplasmic mitochondria were enlarged, but no sign of mitochondrial degeneration was observed. Lamellar degeneration of myelin sheaths and abundant lysosomes were more predominant in group 2 than in group 1. Conclusion: Extracorporeal shock wave lithotripsy caused not only haemorrhage but also damage to neuronal structures except the nucleus. Our findings showed that higher-energy ESWL caused more myelin degeneration in the spinal cord.en_US
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.description.sponsorshipThis study was supported by a grant from the Turkish Neurosurgical Society.en_US
dc.identifier.doi10.1038/sc.2008.31en_US
dc.identifier.endpage632en_US
dc.identifier.issn1362-4393
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.1038/sc.2008.31
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4853
dc.identifier.volume46en_US
dc.identifier.wosWOS:000258916000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofSpinal Corden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectextracorporeal shock wave lithotripsyen_US
dc.subjectspineen_US
dc.subjectcorden_US
dc.subjectelectron microscopyen_US
dc.titleThe effect of extracorporeal shock wave lithotripsy on the rat spinal corden_US
dc.typeArticleen_US

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