Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension

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dc.contributor.authorYavuz, Taner
dc.contributor.authorUzun, Özge
dc.contributor.authorMacit, Aslı
dc.contributor.authorÇomunoğlu, Cem
dc.contributor.authorYavuz, Özlem
dc.contributor.authorSılan, Coşkun
dc.contributor.authorYıldırım, Hayriye Ak
dc.date.accessioned2020-04-30T23:31:32Z
dc.date.available2020-04-30T23:31:32Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSilan, Coskun/0000-0002-8352-6571; silan, coskun/0000-0002-8352-6571en_US
dc.descriptionWOS: 000321090000006en_US
dc.descriptionPubMed: 23582365en_US
dc.description.abstractWe aimed to demonstrate the potential protective effects of pyrrolidine dithiocarbamate (PDTC) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Adult male rats were randomly assigned to 4 groups: control group, MCT-treated rats only, MCT-injected rats treated with PDTC, and PDTC-treated rats only. Blood and tissue samples were collected after the sacrifice. Levels of malondialdehyde (MDA) were measured by using the thiobarbituric acid method. Total antioxidant status (TAS) was determined using a commercially available ImAnOx kit. A histopathological evaluation was accomplished by scoring the degree of severity. Endothelial damage of the main pulmonary artery was evaluated by immunohistochemical labeling of endothelial cells using anti-rat endothelial cell antigen 1 (RECA-1) antibody. MCT-induced right ventricular hypertrophy (RVH) was reduced significantly in the MCT + PDTC-treated group. MDA levels were significantly lowered in the MCT + PDTC-treated group. TAS was significantly higher in the MCT + PDTC-treated group when compared with the rats with PAH. Histopathological examination demonstrated that PDTC treatment reduced the development of inflammation, hemorrhage and congestion, and collagen deposition. In conclusion, PDTC attenuated PAH and protected pulmonary endothelium in rats administered MCT. These findings suggest that PDTC treatment may provide a new effective therapeutic approach in the treatment of PAH. (C) 2013 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.prp.2013.03.002en_US
dc.identifier.endpage308en_US
dc.identifier.issn0344-0338
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2013.03.002
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4290
dc.identifier.volume209en_US
dc.identifier.wosWOS:000321090000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPathology Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMonocrotalineen_US
dc.subjectNF-kappa Ben_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectPyrrolidine dithiocarbamateen_US
dc.titlePyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertensionen_US
dc.typeArticleen_US

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