Prognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patients

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dc.contributor.authorDurnalı, Ayşe
dc.contributor.authorAlkış, Necati
dc.contributor.authorCangür, Şengül
dc.contributor.authorYükrük, Fisun Ardıç
dc.contributor.authorİnal, Ali
dc.contributor.authorTokluoğlu, Saadet
dc.contributor.authorÖksüzoğlu, Berna
dc.date.accessioned2020-04-30T23:21:45Z
dc.date.available2020-04-30T23:21:45Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000323662900059en_US
dc.descriptionPubMed: 23749307en_US
dc.description.abstractThe aim of this retrospective, multicenter study was to evaluate clinicopathological characteristics, prognostic factors and treatment outcomes of teenage and adult patients with high-grade osteosarcoma. A total of 240 osteosarcoma patients who were diagnosed and treated from March 1995 to September 2011 were analyzed. Median age was 20 years (range 13-74 years), and 153 patients (63.8 %) were male. Primary tumor localization was extremity in 204 patients (85.4 %), trunk in 21 patients (8.8 %) and head and neck region in 14 patients (5.9 %). According to American Joint Committee on Cancer staging system, 186 patients (77.5 %) were stage II, 3 (1.3 %) were stage III and 48 (20.0 %) were stage IV. Median overall survival (OS) was 55 months (95 % CI 36.8-73.1 months). OS after 2, 5 and 10 years were 67, 49 and 42 %, respectively. Univariable analysis for OS showed that male gender (p = 0.032), high baseline lactate dehydrogenase (LDH) level (p < 0.001), high baseline serum alkaline phosphatase level (p = 0.002), telangiectatic subtype (p = 0.023), presence of metastasis at diagnosis (p < 0.001), presence of tumor positive margins after primary surgery (p = 0.015), poor pathological response to preoperative chemotherapy (p = 0.006) and presence of recurrent disease during follow-up period (p < 0.001) were significantly associated with poor survival. Patientswho received postoperative methotrexate plus doxorubicin plus cisplatin (M + A + P) combination regimen (p = 0.019), underwent surgery for recurrent disease (p < 0.001) and received chemotherapy for recurrent disease (p < 0.001) had longer OS. Inmultivariable analysis for OS, only high LDH level (p = 0.002) and the presence of metastasis at diagnosis (p = 0.011) were associated with poor OS, whereas the patients who received chemotherapy for recurrent disease had a longer OS (p = 0.009).en_US
dc.identifier.doi10.1007/s12032-013-0624-6en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-013-0624-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4245
dc.identifier.volume30en_US
dc.identifier.wosWOS:000323662900059en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdulten_US
dc.subjectTeenageen_US
dc.subjectOsteosarcomaen_US
dc.subjectPrognostic factorsen_US
dc.titlePrognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patientsen_US
dc.typeArticleen_US

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