Antioxidant therapy impresses in oxidative stress-induced kidney cells

Basit Öğe Kaydı
dc.contributor.authorAlpay, Merve
dc.contributor.authorKısmalı, Görkem
dc.contributor.authorMeral, Öğünç
dc.contributor.authorSel, Tevhide
dc.contributor.authorÖzmerdivenli, Recep
dc.contributor.authorPasin, Özge
dc.date.accessioned2020-04-30T22:39:29Z
dc.date.available2020-04-30T22:39:29Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionMeral, Ogunc/0000-0001-8813-4991en_US
dc.descriptionWOS: 000395357800005en_US
dc.descriptionPubMed: 28814089en_US
dc.description.abstractINTRODUCTION: Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis. They can define the distinction between cancer and normal cells, destroying cancer cells while stabilizing healthy cells. METHODS: apoptotic activities of kidney cells were measured with caspase Elisa kits. DNA laddering test was used to show DNA damage in H2O2 condition. RESULTS: For tumor mechanism, they act as pro-oxidants, producing hydrogen peroxide that attacks the cancer, whereas, in normal conditions they act as protective antioxidants. CONCLUSIONS: The unlike reaction of specific antioxidants should be known at different cell stages. The aim of this study was to assess the antioxidative roles of alpha lipoic acid on kidney cancers during oxidative stress induction (Tab. 1, Fig. 7, Ref 27). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2017_019en_US
dc.identifier.endpage94en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_019
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2741
dc.identifier.volume118en_US
dc.identifier.wosWOS:000395357800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalpha lipoic aciden_US
dc.subjectapoptosisen_US
dc.subjectH2O2en_US
dc.subjectkidneyen_US
dc.subjectROSen_US
dc.titleAntioxidant therapy impresses in oxidative stress-induced kidney cellsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
2741.pdf
Boyut:
215.57 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu