Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods

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dc.authoridKAYA, Cem/0000-0002-1092-3357
dc.authoridBirgul, Kaan/0000-0003-3963-4687
dc.authorwosidbülbül, bahadır/HDM-7433-2022
dc.contributor.authorKaya, Cem
dc.contributor.authorBirgul, Kaan
dc.contributor.authorBülbül, Bahadır
dc.date.accessioned2023-07-26T11:55:06Z
dc.date.available2023-07-26T11:55:06Z
dc.date.issued2023
dc.departmentDÜ, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractThe chirality of molecules is a concept that explains the interactions in nature. We may observe the same formula but different organizations revolving around the chiral center. Since Pasteur's meticulous observation of sodium ammonium tartrate crystals' structure, scientists have discovered many features of chiral molecules. The number of newly approved single enantiomeric drugs increases every year and takes place in the market. Thus, separation or resolution methods of racemic mixtures are of continued importance in the efficacy of drugs, installation of affordable production processes, and convenient synthetic chemistry practice. This article presents the asymmetric synthesis approaches and the classification of direct resolution methods of chiral molecules.en_US
dc.identifier.doi10.1002/chir.23512
dc.identifier.endpage28en_US
dc.identifier.issn0899-0042
dc.identifier.issn1520-636X
dc.identifier.issue1en_US
dc.identifier.pmid36366874en_US
dc.identifier.scopus2-s2.0-85141950621en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4en_US
dc.identifier.urihttps://doi.org/10.1002/chir.23512
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12999
dc.identifier.volume35en_US
dc.identifier.wosWOS:000881735900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBülbül, Bahadır
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofChiralityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAsymmetric Synthesis; Chiral Pool; Chirality; Racemic Mixture; Resolutionen_US
dc.subjectPerformance Liquid-Chromatography; Catalytic Enantioselective Desymmetrization; Polysaccharide Stationary Phases; Diels-Alder Reactions; Human Serum-Albumin; Solid-State Nmr; Asymmetric-Synthesis; Amino-Acids; Capillary-Electrophoresis; Macrocyclic Glycopeptideen_US
dc.titleFundamentals of chirality, resolution, and enantiopure molecule synthesis methodsen_US
dc.typeReview Articleen_US

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