Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods
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Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The chirality of molecules is a concept that explains the interactions in nature. We may observe the same formula but different organizations revolving around the chiral center. Since Pasteur's meticulous observation of sodium ammonium tartrate crystals' structure, scientists have discovered many features of chiral molecules. The number of newly approved single enantiomeric drugs increases every year and takes place in the market. Thus, separation or resolution methods of racemic mixtures are of continued importance in the efficacy of drugs, installation of affordable production processes, and convenient synthetic chemistry practice. This article presents the asymmetric synthesis approaches and the classification of direct resolution methods of chiral molecules.
Açıklama
Anahtar Kelimeler
Asymmetric Synthesis; Chiral Pool; Chirality; Racemic Mixture; Resolution, Performance Liquid-Chromatography; Catalytic Enantioselective Desymmetrization; Polysaccharide Stationary Phases; Diels-Alder Reactions; Human Serum-Albumin; Solid-State Nmr; Asymmetric-Synthesis; Amino-Acids; Capillary-Electrophoresis; Macrocyclic Glycopeptide
Kaynak
Chirality
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
35
Sayı
1
