Effects of Erdosteine on Experimental Acute Pancreatitis Model

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dc.contributor.authorKarapolat, Banu
dc.contributor.authorKarapolat, Sami
dc.contributor.authorGürleyik, Emin
dc.contributor.authorYaşar, Mehmet
dc.date.accessioned2020-05-01T09:11:56Z
dc.date.available2020-05-01T09:11:56Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000416737000004en_US
dc.descriptionPubMed: 29056120en_US
dc.description.abstractObjective: To create acute pancreatitis condition experimentally in rats using cerulein, and to reveal histopathological effects in pancreatic tissue with erdosteine. Study Design: An experimental study. Place and Duration of Study: Department of General Surgery, Duzce University, Turkey, from June to October 2014. Methodology: Thirty male Wistar albino rats were divided into three groups. No procedures were applied to Group 1. The rats in Group 2 and Group 3 were injected cerulein, to establish an experimental pancreatitis model and the blood amylase and lipase values were examined. The rats in Group 3 were given 10 mg/kg erdosteine. This treatment was continued for another 2 days and the rats were sacrificed. The pancreatic tissues were examined histopathologically for edema, inflammation, acinar necrosis, fat necrosis, and vacuolization. Results: The lipase and amylase values and the histopathological examination of pancreatic tissues evidenced that the experimental acute pancreatitis model was established and edema, inflammation, acinar necrosis, fat necrosis, and vacuolization were observed in the pancreatic tissues. The statistical results suggest that erdosteine can decrease the edema, inflammation, acinar necrosis, fat necrosis and vacuolization scores in the tissues. Conclusion: The severity of acute pancreatitis, induced by cerulein in rats, is reduced with the use of erdosteine.en_US
dc.identifier.endpage610en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5819
dc.identifier.volume27en_US
dc.identifier.wosWOS:000416737000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeruleinen_US
dc.subjectInflammationen_US
dc.subjectAcute pancreatitisen_US
dc.subjectErdosteineen_US
dc.subjectTreatmenten_US
dc.titleEffects of Erdosteine on Experimental Acute Pancreatitis Modelen_US
dc.typeArticleen_US

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