Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver

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dc.authoridSoylu, Hakan/0000-0002-1177-2351en_US
dc.authorscopusid58558430200en_US
dc.authorscopusid56239473400en_US
dc.authorscopusid55982152000en_US
dc.contributor.authorAlmali, Eda Nur
dc.contributor.authorKaracor, Kayihan
dc.contributor.authorSoylu, Hakan
dc.date.accessioned2024-08-23T16:03:49Z
dc.date.available2024-08-23T16:03:49Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: Oxidative stress caused by hyperglycemia, which is the most important complication of diabetes mellitus, causes liver damage. Hydroxytyrosol is a polyphenolic compound abundant in olive oil that protects the liver against oxidative damage. Peroxiredoxin 6 (Prdx6) is an anti-oxidative enzyme known to exist in the liver. The aim of this study was to investigate the effect of hydroxytyrosol on Prdx6 expression in diabetes-induced liver injury. Material and Methods: Male Wistar rats were grouped into four as the control group (n=10), hydroxytyrosol group (n=10), streptozotocin group (n=10), and hydroxytyrosol+streptozotocin group (n=10). Blood glucose levels of the animals were measured after streptozotocin injection and at the end of the experiment. The general structure of the liver was examined with a hematoxylin-eosin stain. Prdx6 protein expression was determined with an immunohistochemical method. Results: In the streptozotocin+hydroxytyrosol group, blood glucose level was found to be lower when compared with the streptozotocin group (p<0.001), and histopathological findings in hepatocytes were found to decrease. Prdx6 expression was found to be similar in the control and hydroxytyrosol groups (p=0.590). However, it was found to be higher in streptozotocin and streptozotocin+hydroxytyrosol groups (p<0.001). Prdx6 expression of the streptozotocin+hydroxytyrosol group was found lower than the streptozotocin group (p<0.001). Conclusion: Hydroxytyrosol, the anti-oxidative activity of which has been proven in many studies, was found to relieve blood glucose levels in diabetic rats, cause histopathological changes in hepatocytes, and decrease anti-oxidative Prdx6 expression. This decrease suggested that instead of inhibiting Prdx6, hydroxytyrosol reduced oxidative stress irrespective of Prdx6.en_US
dc.identifier.doi10.18678/dtfd.1259132
dc.identifier.endpage146en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85169470045en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage141en_US
dc.identifier.trdizinid1193856en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1259132
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1193856
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13920
dc.identifier.volume25en_US
dc.identifier.wosWOS:001207170500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectliveren_US
dc.subjecthydroxytyrosolen_US
dc.subjectPrdx6en_US
dc.subjectstreptozotocin.en_US
dc.subjectOxidative Stressen_US
dc.subjectPeroxiredoxin 6en_US
dc.subjectInjuryen_US
dc.titleEffect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liveren_US
dc.typeArticleen_US

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