Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?

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dc.contributor.authorBahadır, Anzel
dc.contributor.authorBaltacı, Davut
dc.contributor.authorTürker, Yasemin
dc.contributor.authorTürker, Yasin
dc.contributor.authorIliev, Darkov
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorSarıgüzel, Yunus Cem
dc.date.accessioned2020-04-30T23:18:46Z
dc.date.available2020-04-30T23:18:46Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000362968700007en_US
dc.descriptionPubMed: 25592102en_US
dc.description.abstractObjective: Obesity causes subclinical inflammation. Leukocyte count and high-sensitivity C-reactive protein (hs-CRP) are used to indicate inflammation in clinical practice. Also, inflammatory markers are evaluated as important indicators of cardiovascular risk in patients with obesity and metabolic syndrome (MetS). We aimed to investigate the usage of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker in obese patients with and without MetS. Methods: The study included a total of 1267 patients. The patients were assigned groups according to degree of obesity and status of MetS. Metabolic and inflammatory markers were compared between groups, and correlation analysis was performed. Results: Leukocyte count and hs-CRP were significantly different (p<0.001), but NLR was not different between body mass index (BMI) groups (p=0.168). Both lymphocyte and neutrophil counts were significantly increased with increased degree of obesity (p<0.001, p=0.028, respectively). Leukocyte, neutrophil, and lymphocyte counts and hs-CRP level showed a significant correlation with BMI (r=0.198, p<0.001; r=0.163, p<0.001; r=0.167, p<0.001; r=0.445, p<0.001, respectively), whereas NLR was not correlated with BMI (r=0.017, p=0.737). Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant association for leukocyte count and NLR (p=0.246; p=0.643, respectively). Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammation in non-diabetic patients with obesity and MetS.en_US
dc.identifier.doi10.5152/akd.2014.5787en_US
dc.identifier.endpage822en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage816en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5787
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3516
dc.identifier.volume15en_US
dc.identifier.wosWOS:000362968700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmetabolic syndromeen_US
dc.subjectneutrophil-lymphocyte ratioen_US
dc.subjectobesityen_US
dc.subjectinflammationen_US
dc.titleIs the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?en_US
dc.typeArticleen_US

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