Cyclooxygenase-2 and Survivin in Superficial Urothelial Carcinoma of the Bladder and Correlation with Intratumoural Microvessel Density

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dc.contributor.authorYıldırım, Ümran
dc.contributor.authorErdem, Havva
dc.contributor.authorKayıkçı, A.
dc.contributor.authorŞahin, A.F.
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorAlbayrak, A.
dc.date.accessioned2020-05-01T09:11:16Z
dc.date.available2020-05-01T09:11:16Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000285404000014en_US
dc.descriptionPubMed: 21309483en_US
dc.description.abstractThis study was designed to investigate the protein levels of cyclooxyogenase-2 (COX-2) and survivin in superficial urothelial carcinoma (UC) and their correlation with microvessel density (MVD). High-grade UC was positive for both COX-2 and survivin protein, and the proportion of tumours positive for both proteins increased with increasing tumour grade. The presence of COX-2 protein was significantly correlated with the presence of survivin protein. Both COX-2 and survivin positivity were significantly correlated with MVD in all patients regardless of tumour grade, but there was no correlation between MVD and COX-2 and survivin positivity by individual tumour grade. Although there was no significant difference in the proportion of COX-2-positive tumours when patients were stratified by tumour stage, a significantly higher proportion of patients with pT1 stage tumours were survivin-positive compared with patients with pTa stage tumours. COX-2 and survivin positivity were significantly correlated in all patients regardless of tumour grade or stage. COX-2 and survivin were significantly correlated in patients with pTa, but there was no correlation in pT1 tumours. These findings demonstrate that together, COX-2, survivin and MVD may play an important role in UC.en_US
dc.identifier.doi10.1177/147323001003800514en_US
dc.identifier.endpage1699en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1689en_US
dc.identifier.urihttps://doi.org/10.1177/147323001003800514
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5449
dc.identifier.volume38en_US
dc.identifier.wosWOS:000285404000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUROTHELIAL CARCINOMAen_US
dc.subjectCYCLOOXYOGENASE-2 (COX-2)en_US
dc.subjectSURVIVINen_US
dc.subjectCANCER GRADEen_US
dc.subjectCANCER STAGEen_US
dc.titleCyclooxygenase-2 and Survivin in Superficial Urothelial Carcinoma of the Bladder and Correlation with Intratumoural Microvessel Densityen_US
dc.typeArticleen_US

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