Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats

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dc.contributor.authorBodur, Akın
dc.contributor.authorKahraman, Cemil
dc.contributor.authorAltay, Diler Us
dc.contributor.authorRendi, Taghi Ahmadi
dc.contributor.authorMenteşe, Ahmet
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2020-04-30T23:18:42Z
dc.date.available2020-04-30T23:18:42Z
dc.date.issued2018
dc.departmentDÜ, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.descriptionBodur, Akin/0000-0001-7413-2717en_US
dc.descriptionWOS: 000425902900032en_US
dc.descriptionPubMed: 29479985en_US
dc.description.abstractBackground/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an enzyme-linked immunosorbent assay. Serum malondialdehyde levels and superoxide dismutase and glutathione peroxidase enzyme activities were determined using colorimetric methods. Results: Final body weight was higher in the obese group (P = 0.007). Serum malondialdehyde concentrations were also higher in the obese group (P = 0.021). Serum glutathione peroxidase activities were higher in the control group (P = 0.028). Serum SCUBE1 levels were also higher in the control group (P = 0.038). Conclusion: There may be no connection between the measured OS parameters and SCUBE1. Differences in SCUBE1 levels may therefore be evaluated independently from OS in obesity.en_US
dc.identifier.doi10.3906/sag-1709-160en_US
dc.identifier.endpage201en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1709-160
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3484
dc.identifier.volume48en_US
dc.identifier.wosWOS:000425902900032en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh fat dieten_US
dc.subjectlipid peroxidationen_US
dc.subjectoxidative stressen_US
dc.subjectobesityen_US
dc.subjectSCUBE1en_US
dc.titleInvestigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese ratsen_US
dc.typeArticleen_US

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