Evaluation of vitamin B12 level in middle-aged obese women with metabolic and nonmetabolic syndrome: case-control study

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dc.contributor.authorBaltacı, Davut
dc.contributor.authorKutlucan, Ali
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorKarabulut, İsmail
dc.contributor.authorYıldırım, Hayriye Ak
dc.contributor.authorÇeler, Ahmet
dc.contributor.authorKara, İsmail Hamdi
dc.date.accessioned2020-05-01T12:14:13Z
dc.date.available2020-05-01T12:14:13Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKARA, ISMAIL HAMDI/0000-0003-2022-1882; KARA, ISMAIL HAMDI/0000-0003-2022-1882; Karabulut, Ismail/0000-0002-1339-5385en_US
dc.descriptionWOS: 000308053300009en_US
dc.description.abstractAim: To investigate the correlation between vitamin B12 and body mass index (BMI) along with insulin resistance (IR) in middle-aged obese women. Materials and methods: The study was designed as a case-control study. The study group included middle-aged obese women and the control group included aged-matched lean women. Weight, height, and hip and waist circumferences were measured. Biochemical parameters such as fasting and postprandial glucose, vitamin B12 and folic acid levels, and lipid profiles were assayed. Results: Enrolled in the study were 116 middle-aged obese and 103 aged-matched healthy lean women. The vitamin B12 level of the obese women was significantly lower than that of the lean women (244.1 +/- 131.5 pg/mL vs. 336.2 +/- 163.1 pg/mL, P = 0.002). However, there was no significant difference in folic acid levels between the groups (P > 0.05). The vitamin B12 level was similar in the obese women with metabolic syndrome and those without (245.1 +/- 145.3 pg/mL vs. 241.2 +/- 96.5 pg/mL, P > 0.05), but the level in the control group was significantly higher than that of patients with obesity and metabolic syndrome (P = 0.010 and P = 0.020, respectively). Vitamin B12 levels correlated with BMI (r = -0.259, P = 0.003) but not with IR (r = -0.053, P > 0.05). Conclusion: The vitamin B12 concentration was low in obese patients and this level negatively correlated with BMI, but not with homeostasis model assessment-estimated IR (HOMA-IR).en_US
dc.identifier.doi10.3906/sag-1105-6en_US
dc.identifier.endpage809en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage802en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1105-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6335
dc.identifier.volume42en_US
dc.identifier.wosWOS:000308053300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectvitamin B12en_US
dc.subjectinsulin resistanceen_US
dc.subjectbody mass indexen_US
dc.titleEvaluation of vitamin B12 level in middle-aged obese women with metabolic and nonmetabolic syndrome: case-control studyen_US
dc.typeArticleen_US

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