In vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole

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dc.contributor.authorKaya, Ayşe Demet
dc.contributor.authorKiraz, Nuri
dc.date.accessioned2020-04-30T23:18:28Z
dc.date.available2020-04-30T23:18:28Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000250274600003en_US
dc.descriptionPubMed: 17944704en_US
dc.description.abstractOtomycosis is worldwide in distribution and most commonly caused by Aspergillus species. Amphotericin B, itraconazole and voriconazole are used for the treatment of aspergillosis, but recently an increase in resistance to these agents has been reported. We aimed at investigating the in vitro activities of amphotericin B, voriconazole and itraconazole against Aspergillus isolates causing otomycosis. Mycological analysis of samples from the ear canals of patients was performed by culturing onto Sabouraud Dextrose Agar and by evaluating microscopically. Aspergillus species were identified with colony morphology and microscopic appearance, and tested for susceptibilities to amphotericin B, itraconazole and voriconazole by the CLSI reference broth microdilution method (M38-A document). A total of 120 isolates from 120 patients, comprising 57 Aspergillus niger, 42 Aspergillus fumigatus, nine Aspergillus flavus, six Aspergillus nidulans and six Aspergillus terreus strains were tested. No resistance was determined against amphotericin B and voriconazole, while six A. fumigatus and three A. niger isolates were resistant to itraconazole. In vitro data obtained in this study showed the resistance to itraconazole, while all of the isolates were susceptible to voriconazole and amphotericin B. Voriconazole seemed to be an alternative in the treatment of infections related to Aspergillus spp. but further studies are needed to learn more about the antifungal resistance of different species of Aspergillus to different agents.en_US
dc.identifier.doi10.1111/j.1439-0507.2007.01409.xen_US
dc.identifier.endpage450en_US
dc.identifier.issn0933-7407
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0507.2007.01409.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3329
dc.identifier.volume50en_US
dc.identifier.wosWOS:000250274600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofMycosesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamphotericin Ben_US
dc.subjectitraconazoleen_US
dc.subjectvoriconazoleen_US
dc.subjectAspergillus sppen_US
dc.subjectotomycosisen_US
dc.titleIn vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazoleen_US
dc.typeArticleen_US

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