The Effect of Treatment on Weight Gain in Iron Deficiency Anemia and Its Association with Ghrelin and Hepcidin Levels

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dc.authoridAnkarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.authoridÖneç, Birgül/0000-0003-2824-1044en_US
dc.authorscopusid58790556800en_US
dc.authorscopusid23988206100en_US
dc.authorscopusid23988222300en_US
dc.authorscopusid23134564000en_US
dc.authorwosidAnkarali, Handan Camdeviren/P-1058-2016en_US
dc.authorwosidÖneç, Birgül/AAA-2012-2021en_US
dc.contributor.authorKilinc, Halil Cansun
dc.contributor.authorOnec, Birgul
dc.contributor.authorOnec, Kursad
dc.contributor.authorAnkarali, Handan
dc.date.accessioned2024-08-23T16:03:49Z
dc.date.available2024-08-23T16:03:49Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: Although loss of appetite in iron deficiency anemia (IDA) and weight gain during treatment are common complaints, there are very few studies in adults. This study aimed to determine the levels of ghrelin, one of the appetite-related hormones, and hepcidin, one of the main regulators of iron metabolism, in IDA, and to examine the effects of treatment on weight gain and the levels of these hormones. Material and Methods: Eighty-seven adult patients with IDA and a control group of 50 healthy volunteers were included in the study. Anthropometric measurements and blood samples were obtained from the patient and control groups before treatment, and repeated after treatment in the IDA group. Results: No significant difference was found in terms of weight, body mass index (BMI), and waist-to-hip ratio between groups but there was a significant increase in weight and BMI, in the patient group after treatment (both p<0.001). Pre-treatment hepcidin and ghrelin levels of the patient group were significantly lower than the control group (p<0.001, and p=0.026, respectively), and hepcidin levels increased significantly after treatment (p<0.001). The increase in ghrelin was not statistically significant but showed a positive weak correlation with both weight (r=0.254, p=0.018) and BMI (r=0.231, p=0.031) increase. Hepcidin levels were not correlated with weight and BMI changes. Conclusion: These findings revealed low levels of ghrelin and hepcidin in adults with IDA and an increase in weight and BMI with treatment. Hepcidin increased with treatment but was not correlated with weight gain, ghrelin was weakly correlated.en_US
dc.description.sponsorshipDuzce University [2015.04.03.396]en_US
dc.description.sponsorshipThis study is supported by the Duzce University Scientific Research Projects Coordinatorship with the project number 2015.04.03.396.en_US
dc.identifier.doi10.18678/dtfd.1323406
dc.identifier.endpage241en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85181209750en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage236en_US
dc.identifier.trdizinid1214338en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1323406
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1214338
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13918
dc.identifier.volume25en_US
dc.identifier.wosWOS:001207169800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIron deficiency anemiaen_US
dc.subjectappetiteen_US
dc.subjectweight gainen_US
dc.subjectghrelinen_US
dc.subjecthepcidinen_US
dc.subjectSerum Hepcidinen_US
dc.subjectAppetiteen_US
dc.subjectExpressionen_US
dc.titleThe Effect of Treatment on Weight Gain in Iron Deficiency Anemia and Its Association with Ghrelin and Hepcidin Levelsen_US
dc.typeArticleen_US

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